Nevertheless, also in the absence of cell-free virus, i.e., upon co-culture of infected epithelial/endothelial cells and monocyte-derived macrophages (moM桅) or dendritic cells (moDC), antiviral responses were induced that limited HCMV spread. The induction of this antiviral effect was ...
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Conflicting reports relating to phagolysosomal pH in CF macrophages have been published, in part related to the use of pH-sensitive fluorescent probes where potential inadequacies in experimental design can be a contributing factor (e.g. employing probes with incorrect pKa for the cellular compartment...
We examined the variability of occurrence and frequency of voltage-dependent whole-cell currents in human peripheral blood monocyte-derived macrophages (HMDM) maintained in culture for up to three weeks. An increase in cell capacitance from an average value of 9 pF on the day of isolation to 11...
We have investigated poly(ADP-ribosyl)ation processes in human monocyte-derived macrophages and the effect of the activating cytokine, interferon γ (IFN-γ) on these processes. IFN-γ was shown to increase the activity of poly(ADP-ribose) polymerase in human macrophages. A 2–3-fold enhancemen...
(circRNAs) are implicated in a variety of physiological and pathological processes; however, the role of circRNAs in macrophages response to Mtb infection remain unknown. To address this issue, here we characterized circRNAs expression profiles in human monocyte derived macrophages (MDMs) response to ...
We present two functions of human IFI16 in the cGAS-STING pathway. Using human phorbol myristate acetate (PMA) treated THP1 cells and human monocyte-derived macrophages (MDMs) depleted of IFI16, we find that early interferon expression in the response to viral infections or DNA transfection requ...
For example, Cluster 62 is enriched in monocyte-derived macrophages and dendritic cells (DC) and contains a set of genes that may have a function in internalisation of apoptotic cells. Cluster 66 contains many genes involved in cytotoxic T cell and NK cell cytotoxic activity, including perforins...
Huang Z, Su R, Deng Z, Xu J, Peng Y, Luo Q, Li J (2017c) Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection. Sci Rep 7:13673 PubMed PubMed Central Google Scholar Huang Z, Su R, Qing C, Peng ...
Moreover, cholesterol enrichment of primary human monocyte-derived macrophages also increased their total as well as TF-positive MV release, and these TF-positive MVs exhibited a similar 10-fold increase in procoagulant activity. To explore the mechanisms of enhanced MV release, we found that ...