Background: Macrophages play a key role in coronary plaque destabilization. In-vitro human monocyte-derived macrophages (MDMs) are used to study macrophages infiltrating tissue. Optical coherence tomography (OCT) provides an in-vivo insight of the coronary arteries. We compared the MDMs morpho-...
MDMMonocyte Derived Macrophages MDMMoi Dix Mois(band) MDMMid-Day Meal(India) MDMMelodic Death Metal(music genre) MDMModern Digital Militia(band) MDMMultiplexer/Demultiplexer MDMMix Design Methods(Langhorne, PA) MDMMarket Development Manager MDMModern Drunkard Magazine(est. 1996) ...
Infection of human monocyte-derived macrophages in vitro with virulent Shigella flexneri resulted in cell death which involved rupture of the plasma membrane, cell swelling, disintegration of ultrastructure, and generalized karyolysis. These features bore resemblance to oncosis and are in striking contras...
We have investigated poly(ADP-ribosyl)ation processes in human monocyte-derived macrophages and the effect of the activating cytokine, interferon γ (IFN-γ) on these processes. IFN-γ was shown to increase the activity of poly(ADP-ribose) polymerase in human macrophages. A 2–3-fold enhancemen...
(circRNAs) are implicated in a variety of physiological and pathological processes; however, the role of circRNAs in macrophages response to Mtb infection remain unknown. To address this issue, here we characterized circRNAs expression profiles in human monocyte derived macrophages (MDMs) response to ...
We present two functions of human IFI16 in the cGAS-STING pathway. Using human phorbol myristate acetate (PMA) treated THP1 cells and human monocyte-derived macrophages (MDMs) depleted of IFI16, we find that early interferon expression in the response to viral infections or DNA transfection requ...
We established a unique model to assess the influence of hyperglycaemia on M1 and M2 differentiation based on primary human monocyte-derived macrophages. The effects of hyperglycaemia on the gene expression and secretion of prototype M1 cytokines TNF-alpha and IL-1beta, and prototype M2 cytokines ...
The effect of serum on low density lipoprotein metabolism of human monocyte-derived macrophages. Macrophages oxidatively modify low density lipoprotein (LDL). These cells then recognize and take up oxidized LDL (OxLDL) via the scavenger receptor. In th... H,Kotake,S,... - 《Tohoku Journal of...
For example, Cluster 62 is enriched in monocyte-derived macrophages and dendritic cells (DC) and contains a set of genes that may have a function in internalisation of apoptotic cells. Cluster 66 contains many genes involved in cytotoxic T cell and NK cell cytotoxic activity, including perforins...
After an initial stimulation of human monocyte-derived macrophages with bacterial lipopolysaccharide (LPS), which produces substantial release of tumor necrosis factor-alpha (TNF-alpha), a subsequent exposure to LPS results in about an order-of-magnitude reduction in the levels of TNF-alpha released....