We demonstrate application of this approach to human genome sequencing on flow-sorted X chromosomes and then scale the approach to determine the genome sequence of a male Yoruba from Ibadan, Nigeria. We build an accurate consensus sequence from >30× average depth of paired 35-base reads. We...
We report here the genome sequence of an ancient human. Obtained from∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an ...
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the...
文章一 1.The complete sequence of a human genome 主要内容:自2000年首次发布以来,人类参考基因组仅涵盖基因组的常染色质部分,而重要的异染色质区域尚未完成。针对剩余 8% 的基因组,端粒到端粒(T2T) 联盟提供了一个完整的30.55亿碱基...
Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with enteroviruses and both are part of the picorn
2009 Building the sequence map of the human pan-genome(我国科学家首提“人类泛基因组”)外语教材.pdf,a n a ly s i s Building the sequence map of the human pan-genome 1,2,7 1,7 1,3,7 1,3,7 1 1 1 Ruiqiang Li , Yingrui Li , Hancheng Zheng , Ruibang Luo , Ho
The Sequence of the Human GenomeJ. Craig Venter,1* Mark D. Adams,1Eugene W. Myers,1Peter W. Li,1Richard J. Mural,1Granger G...
We have combined computational re-analysis of existing whole genome sequence data with novel microarray-based analysis, and detect 12,178 structural variants covering 40.6 Mb that were not reported in the initial sequencing of the first published personal genome. We estimate a total non-SNP variation...
genomehasnonrandom,albeitweaklypositionednucleosomesseI-hypersensitivesites(DHSs)correspondingtoregulatory (Gaffneyetal.,2012).MNase-seq-basedstudieshaveprovidedregions.ProteinandcomplexbindingwithinaDHScreate greatinsightsintotheglobaldistributionanddynamicsofnucle-6–40bpsequencesofseIprotection,calleddigitalse osome...
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets Cell, 161 (2015), pp. 1202-1214 View PDFView articleView in ScopusGoogle Scholar Margolin et al., 2006 A.A. Margolin, I. Nemenman, K. Basso, C. Wiggins, G. Stolovitzky, R. Dalla Favera, A....