DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space th
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space than the human genome using massively parallel...
A map of human genome variation from population-scale sequencing. Nature 467, 1061–1073 (2010). Skaletsky, H. et al. The male-specific region of the human Y chromosome: a mosaic of discrete sequence classes. Nature 423, 825–837 (2003). Article CAS PubMed Google Scholar Yan, S. et...
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Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with enteroviruses and both are part of the picorn
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the...
genome were estimated to be 19~40 Mb, which might have been underestimated considering the study of 10 Danish trios [19]. In a subsequent study [2], re-analysis of the 5 Mb novel sequences from a Chinese individual showed that 3.7 Mb sequences could be aligned to GRCh38 human...
We found that multifractality was mainly dependent on the Alu-S contents (Figure 2B), especially the Alu-Sx, an expected result since these sequences are the most abundant Alu members in the human genome [1]. Analysis via RM confirmed that the Alu sequences tend to be located toward ...
The sequence properties of microsatellites have also been studied in a variety of organisms. Database analyses of genomic sequences have investigated the genome-wide frequency and distribution of microsatellites; such analyses find that the frequencies of microsatellites with different repeat motifs, as ...
cost3,4,5,6. They increase parallelization markedly by imaging many DNA molecules simultaneously. One instrument run produces typically thousands or millions of sequences that are shorter than capillary reads. Another human genome sequence was recently determined using one of these approaches7. However...