Human Protein Atlas(HPA)是一个专注于绘制人类蛋白质分布与表达的综合数据库,由瑞典Knut & Alice Wallenberg基金会于2000年发起,目前已成为全球科研和医学领域的重要工具。其核心是通过多组学技术整合蛋白质在正常组织、肿瘤、细胞系中的定位数据,助力功能研究与疾病机制探索。以下从多个...
THE HUMAN PROTEIN ATLAS,简称HPA,分为Cell,Tissue和Pathology三个版块,分别展示了蛋白在细胞、正常组织和癌变组织中的表达情况。 我以ITGB6为例,实操如何不做实验产数据。 打开proteinatlas.org/,在搜索框中输入ITGB6,点击search 点击图中绿色的Cell,进入该版块。 此版块分5个栏目,分别介绍了ITGB6的详细信息。 C...
首先打开https://www.proteinatlas.org/,在搜索框中输入vimentin,点击search: 界面的第一栏即为要查询的目的蛋白vimentin,我们分别以Cell,Tissue和Pathology三个版块为顺序浏览。 版块一:CELL 点击图中绿色的Cell,进入该版块。此版块分5个栏目,即CELL ALTAS, RNA EXPRESSION, HUMAN CELLS, GENE/PROTEIN和ANTIBODIES A...
需要判断出蛋白质是在哪些细胞结构中,如下是细胞结构图: The Human Protein Atlaswww.proteinatlas.org/learn/dictionary/cell 数据存在样本不均衡的问题(训练集中的某些标签的数量极少): 评价指标 macrof1=mean(2∗recall∗precisionrecall+precision) 1.fastai探索(18.12.3-18.12.5) 这一阶段主要收获是:si...
Recently, we have set-up an animal cell factory using CHO cells with the aim to produce full-length proteins representing all the 2,000 secreted proteins encoded in human genome. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human ...
The Human Protein Atlas releases a new version of its resource each year with expanded data. October 2023One of the key components of the Human Protein Atlas project is the use of primary polyclonal antibodies for identifying and locating the proteins of interest.Atlas Antibodie...
The Human Cell Atlas from a cell census to a unified foundation model This Perspective explores five ways in which cell atlases are revealing valuable biological insights, and how they are poised to provide considerable benefits in the coming years. ...
Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein ...
在CELL部分,我们可以看到这个蛋白在细胞当中的什么部位表达,通过蛋白的表达位置来确定这个蛋白可能具有的功能。 3. 癌症当中的表达情况 在这个部分,数据库汇总了TCGA当中这个基因在RNA-seq当中的表达情况以及数据库自己做的在一部分肿瘤组织当中免疫组化的情况。另外对于基因和预后的关系,这个数据库也分析了TCGA当中预后...
we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. In particular, we discuss cell atlases as censuses of cells; as 3D maps of cells in ...