Fig. 1: A human esophageal cell atlas. aStudy design.bData composition. Number of cells (y-axis; labeled on top of bar) in analysis from each condition (x-axis, left) or location (x-axis, right). The number of samples in each condition from males (M) and females (F) are labeled...
19,20 However, our understanding of how human postnatal thymus niches support conventional and non-conventional T cell development, T-lineage branching, and alternative lineage development remains limited.3,4,6 T cells generated at this stage of postnatal human development will become the foundation ...
Fig. 1: A human esophageal cell atlas. aStudy design.bData composition. Number of cells (y-axis; labeled on top of bar) in analysis from each condition (x-axis, left) or location (x-axis, right). The number of samples in each condition from males (M) and females (F) are labeled...
we systematically interrogated both the cellular sources and sensors of IL-23 in mouse and human TMEs. We identified tumor-associated macrophages (TAMs) as the main cellular source of IL-23 and tumor-infiltrating Tregcells as an IL-23 receptor (IL-23R)-expressing cell type. IL-23 stabilizes ...
the adaptive immune response in the lymphoid structure is key in fighting infections and forming immunological memory, it also became apparent that diverse immune cells including innate and adaptive lymphocytes establish permanent tissue-residency in peripheral organs thus creating a first-line defense ...
Manhattan plot for the Iceland-UK BB meta analyses of asthma (Ncases = 69,189). In all, 56 regions harbor genome-wide significant signals. Variants are plotted by chromosomal position (x-axis) and −log10P values (y-axis). Dotted line indicate the differentPvalue thresholds applied ...
20, implying that cholangiocytes turned into senescence and participated in the bile duct inflammatory response (Fig.2e). Finally, we found that some pro-inflammatory genes were specifically expressed in cholangiocytes (CCL28, CXCL1, CXCL6) and stellate cells (CCL21, CXCL14, TSLP), ...
For example, type 2 innate lymphoid cells (ILC2) activated by tissue damage-induced cytokines interleukins (IL) 25, 33 or thymic stromal lymphopoetin (TSLP) [5], instead of T helper-2 cells, may act as the main producers of pro-allergic cytokines like IL-5, 13 [5] and, to a ...
(Fig.1a), and human T-cell acute lymphoblastic leukemia (T-ALL) Jurkat cells21(Fig.1b). Of note, the binding profile of the TAL1 complex is largely different among these cell types, highlighting the differential usage of lineage-specific enhancers. Based on these data, we selected a ...
line therapy. The currently preferred regimens, FOLFIRINOX or gemcitabine plus nab-paclitaxel (Abraxane), do not extend patient survival by more than 12 months [3,4,5]. To improve the clinical outcomes, a comprehensive understanding of the biological properties of pancreatic cancer cells and other...