These interactions form either homologous or heterodimers, which are then translocated to the cell nucleus, where they bind DNA regulatory elements and induce gene transcription [35, 36]. PD-L1, encoded by the
In the past few years, with a better understanding of how the human immune system works in cancer progression, immunotherapy has become an alternative treatment in both solid and liquid malignancies5. Treatment strategies based on immune checkpoint molecules have been developed6. The programmed death...
We singled out the mutation files which were obtained through the “SomaticSniper variant aggregation and masking” platform for subsequent analysis. The Human Protein Atlas (http://www.proteinatlas.org) was used to investigate the protein levels of metastatic-related genes. Landscape of infiltrating...
a-i, characterization of stromal cell-induced, human MDSCs and monocytes from the same donor. a, arginase activity measured by urea production (106 cells; n = 6 biological independent samples). b, nitric oxide-production (106 cells; n = 5 biological independent samples). c, ROS ...
PD-L1(CD274)表达的增加与肿瘤细胞衰老诱导的程度成正比(图8E和8F)。 由于PD-L1上调可以使癌细胞对靶向PD-1/PD-L1轴的抗体更加敏感,我们在同基因小鼠肿瘤模型中联合使用了阿提莫西利(或帕博西林)和PD-1阻断抗体RN888的小鼠化版本。 在两种测试模型中,尽管从衍生的小鼠肿瘤细胞体外增殖抑制推断出它们的CDK4依赖...
As part of the Human Tumor Atlas Network (HTAN)6, we used single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) and four distinct spatial expression methods (CODEX7,8, targeted ExSeq9, MERFISH10,11,12 and Slide-seq13) to profile tumor biopsies from a cohort of patients with ...
CD274,and HLA-Aexpression in both OC cell lines and OC patients. We also assessed whether TFEB levels in patients with primary OC were related to the expression of PD-L1, PD-L2, and HLA-A. TFEB staining of human OC tissues showed heterogeneous expression, which can be readily ...
In our previous study, we noted that there was no significant difference in PD-L1 (also known as CD274) mRNA levels between BMI1+ CSCs and BMI1− non-CSCs in murine HNSCC (Chen et al., 2017). Surprisingly, analysis of The Cancer Genome Atlas (TCGA) datasets using a machine-learning...
1A). Additionally, although there was nearly a 500% increase in PD-L1 expression in response to IFN-γ treatment, there was no clear indication that PTEN/PI3K signaling impacted total PD-L1 expression levels in either cell line regardless of IFN-γ treatment (Fig. 1A). To determine whether...
Tryptophan metabolism is intricately associated with the progression of colon cancer. This research endeavored to meticulously analyze tryptophan metabolic characteristics in colon cancer and forecast immunotherapy responses. This study analyzed colon ca