To compare the process of muscle aging between species, we generated a mouse muscle aging atlas by sequencing 68,956 cells and 27,573 nuclei from hindlimb muscles of five young (3 months) and three aged (19 months) mice (Fig.1aand Extended Data Fig.2d–g). This atlas yielded the ...
cell type with ageing (column 1) and each single-cell modality (columns 2–4) considering co-variable factors as sex, ethnicity, omics technology and sequencing batch. The colour scale represents the fold change, and the dot size shows the probability of change (local true sign rate (LTSR))...
【Human Cell Atlas】2022年人类细胞图谱大会 2685播放 HCA General Meeting 2022 - Day 1 (AM) 3:48:56 HCA General Meeting 2022 - Day 1 (PM) 2:15:20 HCA General Meeting 2022 - Day 2 (AM) 1:45:20 HCA General Meeting 2022 - Day 2 (PM) part 1 1:50:47 HCA General Meeting 2022 -...
Human Commons Cell Atlas This GitHub repository for the Human Commons Cell Atlas contains uniformly preprocessed and filtered count matrices and cell type assignments that span 29 Human organs as well as marker gene lists for 31 Human organs. The count matrices are in thedatafolder and the marker...
One of the most advanced projects underlying the Human Cell Atlas is the Human Protein Atlas, involving researchers from multiple countries, including Sweden, Denmark, South Korea, China and India. That project, which is continuously updated, offers a glimpse of the kind of work that goes into ...
【33】从人类细胞图谱计划(Human Cell Atlas)谈单细胞基因测序 10972018-03 3 【32】从Bioverative谈血友病疗法:短效、长效、基因治疗(下) 9662018-03 4 【31】从Bioverative谈血友病疗法:短效、长效、基因治疗(上) 9412018-02 5 【30】从Ignyta(被罗氏收购)和Loxo,谈小分子广谱抗癌药 10062018-02 6 【29...
The Human Cell AtlasIan A RyerseJamie M HooftDominique P Bureau
大家好,这里是汉靓的医药科技前沿的第33期。我相信多数人对于从1990年到2003年的人类基因组计划(Human Genome Project)记忆犹新,在这项耗时13年的巨大工程中,来自全球六个国家20多个科研机构的科学家齐心协力,共同绘制出人类的全基因组图谱,为精准医学的推进打下了坚
36 free DNA is more likely to be degraded upon cell death and hence will be under-represented in 37 cfDNA 8. Ulz et al. used this concept to infer gene expression in the cells contributing to cfDNA 9. 38 The latter can theoretically indicate not only the tissue origins of cfDNA, but ...
While single-cell technologies have greatly advanced our comprehension of human brain cell types and functions, studies including large numbers of donors and multiple brain regions are needed to extend our understanding of brain cell heterogeneity. Integrating atlas-level single-cell data presents a chan...