Differentiation of CD34+ cells from human cord blood and murine bone marrow is suppressed by C6 beta-chemokines. Mol Cells 15: 176-180.Han, I.S., et al., Differentiation of CD34+ cells from human cord blood and murine bone marrow is suppressed by C6 beta-chemokines . Mol Cells, 2003....
CD34 is a cluster of differentiation (CD) first described independently by Civin et al. and Tindle et al.[6][7][8][9] in a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or dir...
Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induce... It has been suggested that epigenetic regulation plays an important role in maintaining the stemness and lineage differentiation of hematopoi...
The most effective antigen-presenting cells for T lymphocytes are dendritic cells (DCs), the differentiation pathway of which, however, is incompletely characterized. We examined here how DCs differentiated from human cord blood CD34+ progenitor cells cultured with granulocyte- macrophage colony-stimulatin...
Because CD34+ cells can stimulate an allogeneic T-helper 1 (Th1) response in vitro,22 we evaluated whether T cells can drive the differentiation of CD34+ cells into functional APCs. Multiple cytokines, including GM-CSF and TNFα, are capable of inducing the differentiation of hematopoietic ...
We investigated the phenotypic changes of human umbilical cord blood (CB) CD34+ cells during ex vivo expansion using thrombopoietin (TPO), flt3-ligand (FL), and/or granulocyte-colony stimulating factor (G-CSF). During ex vivo expansion of CD34+ cells isolated from human CB for up to 5 week...
It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. CD34是糖基化的跨膜蛋白,是原代血细胞和骨髓来源祖细胞(尤其是造血细胞)的典型表面标记。尽管CD34+细胞的功能现在还不清楚,但研究表明,CD34+细胞涉及维持造血祖细胞的未分化状态。北京诺为生物...
CD34+ cells isolated from bone marrow or umbilical cord blood from healthy donors were studied for proliferation and differentiation in liquid cultures in the presence of recombinant human granulocyte-monocyte colony-stimulating factor (GM-CSF), granulocyte CSF (G-CSF), monocyte CSF (M-CSF), and ...
Hematopoietic stem cells are capable of self-renewal and differentiation into different hematopoietic lineages. To gain a comprehensive understanding of hematopoietic stem/progenitor cells, a systematic proteomic survey of human CD34+ cells collected from human umbilical cord blood was performed, in which ...
Because CD34+ cells express low levels of CD4, the primary receptor of the human immunodeficiency virus (HIV), and CXCR4 is a coreceptor for T-cell tropic (X4) HIV strains, we investigated the susceptibility of CD34+cells to infection by this subset of viruses. Lack of productive infection ...