The combination of adenosine deaminase inhibition and deoxyadenosine induces apoptosis in a human astrocytoma cell line. Alterations in the functions of astrocytes contribute to the appearance of a variety of neurological pathologies. Gliomas, especially those of astrocytic o... M Garcia-Gil,MG Tozzi,...
The cell line has been established from human foetal tissue. The cell line has been immortalised using a retroviral vector containing the v-myc oncogene. The cell line is a neural progenitor cell line capable of differentiating into to astrocytes and neurons including dopaminergic neurons. NGC-407...
Astrocytes are the most abundant cell type in the brain. They were long considered only as passive support for neuronal cells. However, recent data have revealed many active roles for these cells both in maintenance of the normal physiological homeostasis in the brain as well as in neurodegenerati...
Subsequently, we annotated the cell types using SingleR and canonical marker genes for neural cells. Specifically, we categorized the cells into six major lineages: neurons (Syt1, Map2, Gad1, and Ahcyl2), astrocytes (Gja1, Aqp4, and Bag3), oligodendrocytes (Mobp, Plp1, Ugt8, and Apod)...
TIMP-1 is expressed by variety of cell types including astrocytes61, and is known to be able to shift microglia from an M1 to an M2 state62,63. In LPS-activated microglia cocultured with EVs, TIMP-1 was increased supporting an anti-inflammatory role of EVs on microglia. BDNF, which is...
along with differential expression analysis and statistical tests on cell groups. The CellChat algorithm with default parameters (unless otherwise specified) was applied to the sub-set of the dataset that corresponded to microglia and astrocytes, separately on the AD and NDC samples. The human CellCha...
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. The effect of cytokines on astrocytes cultured from mature bovine brain was determined both in a serum-containing medium and in a chemically-defined medium... KW Selmaj,M, Farooq,WT Norton,...
Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of a number of pathologic abnormalities, including adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The viral oncoprotein Tax has been implicated in the pathogenesis of these...
The glial environment is an important determinant of neuronal health in experimental models of neurodegeneration. Specifically, astrocytes have been shown, dependent on context, to be both injurious and protective. Human pluripotent stem cells offer a po
astrocytes seems to be the prevailing mechanism across various neuropathologies. In addition, cell autonomous primary astrocytopathies can give rise to aberrant astrocytes which drive neuropathological progression, and there is now mounting interest in how astrocytes that are reactive or diseased might...