结果病毒感染KFs 48 h后,hsa-miR-199a-5p组的hsa-miR-199a-5p表达量明显高于rLv-NC组和空白对照组,差异有统计学意义(P<0.01);与rLv-NC组和空白对照组相比,hsa-miR-199a-5p组的细胞增殖率、侵袭性均有所降低,细胞凋亡率...
miR-199a-5p increased the growth rate of cardiomyocytes after treatment with a hypoxic environment. miR-199a-5p acted as an inhibitor directly targeted hypoxia-inducible factor-1 (HIF1伪) expression, which was higher in the cardiomyocyte injury model than that in healthy myocardial cells. Up...
Subsequent assays revealed that hsa_circ_0060450 can serve as the sponge of miR-199a-5p, release its target gene, Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the tyrosine-protein phosphatase non-receptor type 11 gene (PTPN11), and further suppress the ...
货号:hsa-miR-199a-5p 原价:￥2730 现价:￥2100.00节省:￥630 规格:1 kits 说明:hsa-miR-199a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转...
Recently, microRNA 199a-5p (miR-199a-5p) has been recognized as a vital regulator in several human diseases. Nevertheless, the function of miR-199a-5p and the associated downstream molecular mechanisms in myocardial injury remain undescribed. Here, we assessed the relative expression of miR-199...
目的:探讨hsa-miR-199a-5p在缺血性脑卒中(IS)患者血清中的表达和意义.方法:收集118例IS患者及125例健康人群的血清标本.通过实时荧光定量PCR(q PCR)检测血清hsa-miR-199a-5p的表达,用ROC曲线分析hsa-miR-199a-5p表达应用于诊断IS的价值,并对hsa-miR-199a-5p表达与研究人群的临床特征进行相关性分析.结果:hsa...
In addition, among the hypothyroidism patients, hsa-miR-199a-5p level in water iodine >100 µg/L group was remarkably higher than that in 10-100 µg/L group. Furthermore, HIF-1α and PD-L1 mRNA levels in whole blood were determined, which are the target genes regulated by miRNA-...
the hsa-miR-21-5p/hsa-miR-199a-5p ratio could discriminate the HCC from the LC group at AUC = 0.76, 94% sensitivity, and 48% specificity at cutoff >11.45. hsa-miR-155-5p/hsa-miR-199a-5p ratio distinguished the two groups at AUC = 0.71, 92% sensitivity, and 53% specificity at ...
hsa-miR-199b-5p慢性肾脏病足细胞生物信息学靶基因目的:初步论述miR-199b-5p的生物学功能。方法:首先我们应用miRbase、UCSC等数据库,对miR-199b-5p的序列进行了保守性分析;然后选择miranda、miRDB及TargetScan三个数据库预测hsa-miR-199b-5p的靶基因,取其交集;最后运用基因GO功能注释以及KEGG信号转导通路富集分析...
To test the silencing potential ofmiR-199b-5pon PODXL, miRIDIAN Mimichsa-miR-199b-5p(and negative control) were transfected in THP-1 and HeLa cells. Analysis of PODXL transcript levels post transfection confirmed that PODXL is indeed a strong target ofmiR-199b-5p. This was further ...