(median = 3.18-fold change vs. 1.81-fold change,p= 0.001). On the other hand, no significant difference was detected between groups regarding hsa-miR-192-5p expression. However, the HCC group showed significant down-regulation of plasma hsa-miR-199a-5p in comparison to the LC group as ...
中hsa-miR-654-5p过表达时,BMP2的mRNA和蛋白表达水平均发生明显下调;双荧光素酶报告基因检测提示,BMP2的预测 靶位点直接受hsa-miR-654-5p的抑制调控,该靶位点被突变后hsa-miR-654-5p对BMP2的抑制作用消失.结论 hsa-miR-654-5p可通过作用于BMP2的特定靶位点而直接抑制BMP2的mRNA和蛋白表达.hsa-miR-654-5p...