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Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo ...
It is therefore a ‘must’ to include at least one, but preferentially several reference compounds in each assay. 7.1.1. Agar-diffusion methods In the diffusion technique, a reservoir containing the test compound at a known concentration is brought into contact with an inoculated medium and the...
How to further develop quality competition in the German healthcare system? Results of a Delphi expert study Introduction: Many international healthcare systems use quality competition to improve the quality of care. The corresponding instruments include quality m... D Negele,M Lauerer,E Nagel,.....
Sponsors can develop either an individual method or a matrix of methods to measure product potency. In general, a fit-for-purpose or qualified potency assay based on protein or even mRNA expression after vector transduction could be sufficient during clinical development stage for investigational ...
用Swing组件来制作软件的界面 This design main purpose is the design manufactures one section based on the JAVA matrix operation software.This software uses the Myeclipse tool platform to carry on the development, used the Jama tool bag in the manufacture process to develop the software the function...
ait has never been an easy job for global advertisers to create this message. But no matter how difficult this job may be, it is very important for global advertisers to do it well.In today's competitive world,most new products quickly fail. 它从未是一个容易的工作为了全球性登广告者能创造...
Fragment-based drug discovery (FBDD) has proven a powerful method to develop novel drugs with excellent oral bioavailability against challenging pharmaceut... C Dan,JC Errey,LH Heitman,... - 《Acs Chemical Biology》 被引量: 48发表: 2012年 Virtual fragment screening on GPCRs: A case study ...
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