Key interactions are indicated as dotted lines. Active-site Mg2+ ions are shown as green spheres, and water molecules are shown as magenta spheres. Note that 3 -OH of the primer terminus is not coordinated to the catalytic metal ion. The distance between 3 -OH of the primer...
Another technique to improve diagnosis of liver lesions is the use of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a specific MRI contrast agent of liver and bile that is formed by adding fat-soluble ethoxybenzyl (EOB) [132]. Gd-EOB-DTPA shortens T1 relaxation tim...
The patterns along the DNA formed by these chemical marks instruct the cell which proteins to express and their faithful maintenance after replication are vital to the organism's life. Although Dnmt1 is the enzyme catalyzing the methylation reaction, it was found that UHRF1 (ubiquitin-like, ...
Crystal structures of apo IscR dimers alone and in complex with the type 2 regulatory site are available (Fig. 6a)16,17. They have shown that apo IscR is already well poised to bind DNA at that site because the differences between its bound and unbound conformations are small. Ser40, Glu...
It remains theoretically possible that isoforms may work together as trimers, rather than dimers, with two groups of three isoforms for each of the six subcomplexes of the rosette. It has been noted, however, that there might not be a need for a multimeric enzyme if each cellulose synthase...
Surprisingly, despite its function as an accurate and efficient TLS polymerase for UV induced pyrimidine dimers, the levels of Pol η actually decrease following UV irradiation in human and murine cells [42,92] (see Section 4.3). Pol η levels are induced following treatments that create double ...