Another technique to improve diagnosis of liver lesions is the use of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a specific MRI contrast agent of liver and bile that is formed by adding fat-soluble ethoxybenzyl (EOB) [132]. Gd-EOB-DTPA shortens T1 relaxation tim...
Indeed, ChIPseq data show that, while physiologically expressed Prep1 or Meis1 bind to their specific target sequences, overexpressed Prep1 or Meis1 tend to mainly target genes that are normally bound by the AP1 oncogene (one of the fos-jun dimers), which has just a similar DNA target ...
It remains theoretically possible that isoforms may work together as trimers, rather than dimers, with two groups of three isoforms for each of the six subcomplexes of the rosette. It has been noted, however, that there might not be a need for a multimeric enzyme if each cellulose synthase...
These experiments strongly suggest that native Aβ dimers from AD patients are sufficiently neurotoxic to trigger AD features, such as tau hyperphosphorylation and neurodegeneration. Table 2. Selection of recent key data obtained from AD primary culture models. 4.1.2. Neurons In many AD cellular ...
Surprisingly, despite its function as an accurate and efficient TLS polymerase for UV induced pyrimidine dimers, the levels of Pol η actually decrease following UV irradiation in human and murine cells [42,92] (see Section 4.3). Pol η levels are induced following treatments that create double ...