Different from the previous work in Diels–Alder (D–A) dimerization of cyclopentadienone41, five-membered-ring-bridged dimers are formed in this study due to the presence of KOH, a strong base, in the reaction mixture. To further investigate this reaction, we replaced 1b (R = Me)...
Examination of the binding of FeBABE-conjugated BvgA to the fha promoter of Bordetella pertussis has revealed that three dimers, formed by head-to-head ass... PE Boucher,AE Maris,MS Yang,... - 《Molecular Cell》 被引量: 113发表: 2003年 Glycyrrhizin and some analogues induce growth of pri...
CO2 lasers emit energy in the far-infrared, and are used for cutting hard materials. Excimer Lasers Derived from the terms "excited" and "dimers," these types of lasers use reactive gases, such as chlorine and fluorine, mixed with inert gases such as argon, krypton or xenon. When ...
Both cancer and fibrosis are diseases involving dysregulation of cell signaling pathways resulting in an altered cellular microenvironment which ultimately leads to progression of the condition. The two disease entities share common molecular pathophysiology and recent research has illuminated the how each pr...
In practice, statistical effects would lead to a bowed titration curve (for example, at 50% occupancy, the distribution of dimers expected is 25% each of 0,0; 0,1; 1,0; and 1,1, where 0 and 1 are vacant and myxothiazol inhibited sites, so 75% of the full reduction might be ...
A key element is that the dimers are not stable, being continuously formed and disrupted, in agreement with recent data51. An important validated prediction of the EAM concerns the response of EGFR ubiquitination to variations in EGFR levels. The system exhibits a complex behaviour that depends ...
In addition to its role in base-excision DNA repair, pol has been implicated in the translesion synthesis of various types of DNA damage such as 8-oxoguanine, cisplatin-GG intrastrand cross-link adducts and UV-induced cyclobutane pyrimidine dimers (20). The plethora of kinet...
A) lumen of the GI tract; B) loose mucus layer containing commensal microorganisms; C) firm mucus layer containing antibodies (mucosal IgA dimers), and antimicrobial products produced by goblet cells and other epithelial and immune cells; D) lower bowel (colon) epithelium containing epithelial ...
Dimers are formed between the blue central molecule and the colored neighbors. Note that the same color indicates identical charge pathways. B3LYP/6-31G* computed electronic couplings, 𝑉𝑖𝑗Vij, are also reported. 3. Computational Methods We performed gas–phase quantum chemical calculations...
The AP sites may be formed after the accumulation of uracil in the DNA strand, which is caused by hydrolytic deamination of 5-methylcytosine. As a result, the U-G pairs are created, which, if not repaired before replication, will lead to C/G to T/A mutations. In this case, the BER...