Case Presentation: We present four cases of secondary HLH in adults with varying presentations with a variety of underlying triggers including EBV infection, T cell lymphoma and blinatumomab therapy. Conclusion: HLH has multifaceted clinical presentations with often non-specific signs and symptoms that ...
儿童期多见HLH,not an independent disease entity, but rather a clinical syndrome or a constellation of symptoms and signs前言 (Introduction)国际组织细胞学会组织细胞疾病现代分类(Contemporary Classification of Histiocytic Disorders)生物学行为各异的组织细胞疾病(Disorders of varied biological behavior) 树突状...
HLH起病急、病情进展迅速、病死率高，为一种潜在致死性疾 病(potentiallyfataldisease)。儿童期多见 HLH，notanindependentdiseaseentity,butratheraclinicalsyndromeoraconstellationofsymptomsandsigns 国际组织细胞学会组织细胞疾病现代分类 （ContemporaryClassificationofHistiocyticDisorders）生物学行为各异的组织细胞疾病（...
syndromeoraconstellationofsymptomsandsignssyndromeoraconstellationofsymptomsandsigns 前言(Introduction) 国际组织细胞学会组织细胞疾病现代分类国际组织细胞学会组织细胞疾病现代分类 ((ContemporaryClassificationofHistiocyticDisordersContemporaryClassificationofHistiocyticDisorders)) 生物学行为各异的组织细胞疾病生物学行为各异的组织...
Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening emergency and any delay in diagnosis and/or treatment is associated with high mortality. It is rarely observed in adult patients. HLH has multifaceted clinical presentations with often non-specific signs and symptoms that are ofte...
10 GENERAL BACKGROUND 11 INTRODUCTION 12 Summary of the HLH-94 results 12 DIAGNOSIS AND CLINICAL PRESENTATION 13 TABLE 2: Diagnostic guidelines for HLH-2004 15 THERAPEUTIC BACKGROUND 16 CONCLUSIONS FROM HLH-94 17 GENERAL STUDY DESIGN 19 Patients eligibility 20 Pre-treatment investigations 20 ...
ORF1 genotype.9 Horne et al found a higher prevalence of perforin mutations in patients from the Middle East and syntaxin mutations in Turkish patients compared with Nordic patients.10 They found no differences in presenting signs and symptoms based on genotype, but reported that patients with perf...
Diagnosis is challenging due to the variability in signs and symptoms, which may include fevers, swelling of the liver and spleen, severe low red and white blood cell counts, bleeding disorders, infections, neurological symptom...
(ED) with a three-day history of flu-like symptoms, fever, erythematous rash, widespread joint pain, nausea and chills. Acute Dengue virus infection was confirmed with serum polymerase chain reaction (PCR) testing. On day two, she was admitted to intensive care for multi-organ support ...
Visceralorganinvolvement+/-bonelesions,diabetesinsipidus,adjacentlymphnodeinvolvement,and/orrash withoutsignsoforgandysfunctionofthelungs,liver,orhematopoieticsystem Visceralorganinvolvement+/-bonelesions,diabetesinsipidus,adjacentlymphnodeinvolvement,and/orrash ...