HLH is a rare condition, which is fatal in a high percentage of patients. It is characterised by systematic inflammatory disorder and dysfunction of multiple organs, which has also a genetic origin [73,75]. Besides acquired risk factors in non-inherited form, also an inherited form of the di...
HLH can occur as a primary genetic disorder or a secondary consequence of another medical condition, including infection (9). Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans Studies demonstrate that CNS involvement, i.e., neurological symptoms...
MAS is a rare, life-threatening condition characterised by uncontrolled hyperinflammation which may develop on a background of rheumatic diseases such as sJIA. It is classified as a secondary form of HLH and is caused by excessive activation and expansion of T cells and macrophages. Biovitrum AB ...