Hemophagocytic lymphohistiocytosis (HLH) is a rare, cancer-like disorder in which histiocytes and lymphocytes proliferate and damage body tissues or organs. Enlarged lymph nodes, spleen, and liver, rash, and changes in blood cell counts are symptoms and
GO terms related to immune response and metabolic process are highlighted in red. d Heat maps of fold changes for mRNA levels of lipid metabolism genes in hlh-11 KO and OE worms. The fold changes are calculated by dividing the mRNA level of each indicated gene in hlh-11 KO or OE ...
f–h GO-term enrichment analyses, conducted on the co-activated and co-repressed genes shown in c–e. Only GO-terms of significant enrichment are shown (DAVID score ≥ 1, *: here the term aging was amongst the 12 most enriched GO-terms, but its score was only 0.62 and therefore below...
Noticeably, innate immune response terms such as ‘defense to bacterium’ or ‘defense to external stimuli’ are also enriched, supporting a role for pgph-2 in the promotion of healthy aging39,40,41,42 and the possible involvement of hlh-30 in this response (Fig. 3c). Thus, HLH-30 is...
2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original ...
We performed a scoping review of the literature following PRISMA guidelines by searching the PubMed/Medline database for articles reporting cases of tick-borne infections associated with HLH, using the following search terms: “tick borne illness and HLH OR tick borne illness and hemophagocytic lympho...
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Share and Cite MDPI and ACS Style Stadermann, A.; Haar, M.; Riecke, A.; Mayer, T.; Neumann, C.; Bauer...
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