Full size image HLH-11 belongs to a family of bHLH transcription factors27,28. The signature HLH domain normally mediates protein dimerization and is required for DNA binding. Deletion of the HLH domain in HLH-11 did not affect its nuclear localization (Supplementary Fig. 2e), but the mutant...
Subsequently, a chimerism analysis conducted in the bone marrow shortly thereafter revealed a state of the complete remission of hemophagocytic lymphohistiocytosis (HLH), concurrent with full chimerism. A progression-free survival of 6 months was reached until our patient developed severe chronic graft-...
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Full size image RNA-seq analysis reveals catabolic and longevity signatures with pgph-2 o/e To assess the genes differentially regulated by pgph-2 and that could provide insight into the understanding of the glycerol shunt in healthy aging, and to determine the subset of pgph-2-regulated genes...