To test this possibility, we first measured the fat content in hlh-11 KO males or L4 stage worms, which do not transfer lipids to fulfill the energy demands of embryos. The fat loss phenotype was also observed in hlh-11 KO males or L4 stage worms (Supplementary Fig. 4c–f). Moreover...
We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (spermatogenesis and oogenesis specific basic helix–loop–helix (bHLH) transcription factor). In males, Sohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia. Loss of Sohlh1 causes ...