Apart from fever and splenomegaly, clinical presentation frequently comprised hepatomegaly, liver failure, hyperbilirubinemia, renal failure, lung involvement like ARDS, or bleeding. Treatment included steroids in the vast majority of pts (n=89), often combined with i.v. immunoglobulins (n=47) and...
612 Words 3 Pages Open Document Try Paraphrasing tool INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is an incompletely understood condition resulting in uncontrolled and ineffective immune activation. HLH is classified as genetic HLH (primary) or acquired (secondary) and presents with a fulminant ...
The causes of death in 4 patients who did not have active HLH at death (■) were: fatal bleeding following liver biopsy (n=1, 7th week); septicemia where HLH status at death is not known (n=1, 2nd week), and cause of death not stated (n=2, 1st and 38th weeks). One patient ...
Diagnosis is challenging due to the variability in signs and symptoms, which may include fevers, swelling of the liver and spleen, severe low red and white blood cell counts, bleeding disorders, infections, neurological symptoms...
Both bleeding episodes occurred despite stable platelet counts > 40G/L. Following re-introduction of anti-inflammatory treatment, the patient recovered without prolonged sequelae and was discharged home on day + 88.doi:10.1007/s10875-023-01522-7Maria Elena,Maccari...
Immunization did not change the menstrual regularity; bleeding days were normal (3–7 days) and 89 % of the menstrual cycles were within the normal range of 22–35 days. Irregular (short or long) cycles were observed in both immunized and control groups. These were, however, unrelated to ...