Intriguingly, a subset of genotypes was observed to have significant but opposite impact on HHV infection versus disease phenotypes (Fig.1D). A compound genotype encoding KIR2DS4 and its ligand A*11:02 is observed to be associated with reduced EBV/IgA/VCA seroconversion, a risk factor for NPC...
Monocytes from C08 were characterized by upregulated level of HLA-DRA and HLA-DRB1, which closely resembled CD14+HLA-DRhigh inflammatory monocyte. C10 monocytes exhibited high expression of S100A family genes, including S100A8 and S100A12, along with low expression of HLA-DR, reminiscent of HLA...
The TruSight HLA Sequencing Panel Library Preparation protocol provides: } A single assay and workflow to obtain ultra-high-resolution sequencing of 8 HLA Loci (Class I HLA-A, -B, -C; Class II HLA-DRB1/3/4/5, -DQA1, -DQB1, ...
HLA-DRB1*0103IL23RTNFRSF1ABackground: Crohn's disease (CD) and ulcerative colitis (UC), 2 major forms of inflammatory bowel disease (IBD), are complex disorders with significant genetic predisposition. The first CD-associated gene, CARD15/NOD2 , was recently identified and since then several ...
专利名称:抗hla-dr抗体的制作方法 技术领域:本发明涉及可识别人类白细胞抗原-DR(HLA-DR)的抗HLA-DR抗体,该抗体是与免疫性相关的细胞膜分子。此外,本发明涉及所包含有效成分为抗HLA-DR抗体的下列两类药剂(1)用于由HLA-DR表达细胞所引起疾病的预防或治疗性药剂,尤其是用于恶性肿瘤的治疗性药剂;和(2)用于由HLA-...
10. The method of claim 9, wherein the gene(s) of interest are an HLA-A gene, an HLA-B gene, an HLA-DRB1 gene, an HLA-DQA1 gene, or an HLA-DQB 1 gene. 11. The method of claim 9, wherein hybridizing is performed on HLA-Chips containing microarrays. 12. The method of claim...
Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11:46–52. https://doi.org/10.1111/j.1463-1326.2008.01002.x. Article PubMed PubMed Central Google Scholar Pujol-Borrell R, Todd I, Doshi M, Bottazzo GF,...
Positive internal control amplicon with primer sequences (F: 5′-TGCCAAGTGGAGCACCCAA-3′; R: 5′-GCATCTTGCTCTGTGCAGAT-3′) giving a 779 bps product (HLA-DRB1 intron sequence) was run with each sample to check for PCR failure. SNP selection and Genotyping. Three SNPs were selected ...
doi:10.1016/j.ijcard.2007.03.081Anil Palikhe and Marja-Liisa Lokki and Pekka Saikku and Maija Leinonen and Mika Paldanius and Mikko Seppänen and Ville Valtonen and Markku S. Nieminen and Juha SinisaloInternational Journal of Cardiology...
Some of the HLA alleles that showed associations with COVID-19 progression or response to the vaccine were predicted in this analysis to bind to self-epitopes showing 90% BLAST homology with the BNT-162b2 mRNA vaccine protein. For example, the HLA-DRB1*15:01 allele, predicted to bind epitop...