乙型肝炎患者外周血单核细胞CD14^+CD16^+亚群及HLA-DR的检测及其意义
HLA-DR结构性表达在抗原递呈细胞上,主要表达于免疫系统的细胞[1]。HLA-DR在单核细胞上强表达,尤其是CD14+CD16+亚群[2];在巨噬细胞、粒细胞、浆样树突状细胞、小胶质细胞、郎格汉斯细胞上亦可表达[1,3,4]。HLA-DR还可表达于一些造血细胞的幼稚阶段,例如BFU-E,但不表达在CFU-E或原红细胞[5]。本产品为...
Monocyte subset composition was determined by flow cytometry based on the expression of CD14, CD16, and HLA-DR. Monocyte subset composition and the expression of CD14 and HLA-DR were correlated with patient outcomes. The results were compared to 19 patients with coronary artery disease. Cardiac ...
急性脑梗死患者单核细胞CD14+CD16+亚型的表达变化及临床意义 热度: 皮肌炎患者外周血单核细胞PD-L1分子的表达及其临床意义① 热度: ·临床研究· HLA-DR / CD14 在外周血单核细胞中的表达及其临床意义 李薇,谢闻悦,张卫云,张璇,张玉新,高贵阳 [摘要] ...
2.HLA-Ⅱ类基因 HLA-Ⅱ类基因区包括近30个基因座,其中经典的Ⅱ类基因一般指DR、DP和DQ,它们编码的产物均为双肽链(α、β)分子。近年来,陆续发现了一些位于Ⅱ类基因区的新基因座,其中某些基因的产物与内源性抗原的处理与呈递有关。 3.HLA-Ⅲ...
This analysis resulted in nine distinct clusters: CD4+ T cells, CD8+ T cells, CD8+ effector T cells, B cells, NK cells, CD14+ monocytes, CD16+ monocytes, myeloid cells and dendritic cells. Differential expression analysis between CD8+ and CD8+ effector T cells for the third time point ...
本发明专利技术涉及用诸如微管抑制剂、PARP抑制剂、布鲁顿激酶抑制剂或PI3K抑制剂的药物与针对HLA‑DR或Trop‑2的抗体或免疫缀合物进行的组合疗法。当使用免疫缀合物时,它们优选地并有SN‑38或pro‑2PDOX。免疫缀合物可以介于1 mg/kg与18 mg/kg之间,优选是4、6、8、9、10、12、16或18 mg/kg,更优选...
Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S (2013) Increase in CD14 + HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. Cancer Immunol Immunother 62(8):1421–1430. https://doi.org...
Myeloid derived suppressor cells are present and predominantly localized in the ONB stroma To identify myeloid cells in the ONB TIME a mxIF panel of C11b, HLA-DR, CD14, CD15, CD68, and synaptophysin was used (Fig. 2A). Recent studies have shown that CD68+ is overexpressed in tumor asso...
anti-Human CD127 (Mouse monoclonal) BioLegend Cat# 351356; Clone A019D5; RRID: AB_2800937 anti-Human CD195 (Rat monoclonal) BioLegend Cat# 359137; Clone J418F1; RRID: AB_2810570 anti-Human HLA-DR (Mouse monoclonal) BioLegend Cat# 307663; Clone L243; RRID: AB_2800795 anti-Human IgG...