蛋白酶抑制剂(Protease inhibitor,PIs)是肽类的化合物,是开发的第二类抗逆转录病毒药物,广 […] 蛋白酶抑制剂(Protease inhibitor,PIs)是肽类的化合物,是开发的第二类抗逆转录病毒药物,广泛用于治疗HIV / AIDS和丙型肝炎(HCV)。蛋白酶抑制剂通过选择性结合病毒蛋白酶(例如HIV-1特异天冬酰蛋白酶),并阻止产生感染...
HIV-Protease Inhibitoren HIV protease inhibitorsTominaga Toda-shi FukazawaRyohei Toda-shi KatoYoshiaki Ibaraki-shi KisoTsutomu Toda-shi MimotoNaoko Toda-shi Morohashi
PIs:Protease Inhibitors,即蛋白酶抑制剂,这些药物通过阻止病毒蛋白酶的活性来抑制HIV-1。 INSTIs:Integrase Strand Transfer Inhibitors,即整合酶链转移抑制剂,是一类抗HIV药物,通过抑制整合酶来阻止病毒整合到宿主DNA中。 INBIs:Integrase Binding Inhibitors,即整合酶结合抑制剂,这些药物通过不同的机制抑制整合酶活性。
HIV PROTEASE INHIBITORS 专利名称：HIV PROTEASE INHIBITORS 发明人：ALBIZATI, Kim, F.,REICH, Siegfried,VARNEY, Michael, D.,ZHANG, Kanyin, E.,KOBAYASHI,Takuo 申请号：EP98910300.7 申请日：19980312 公开号：EP0970055A2 公开日：20000112 专利内容由知识产权出版社提供 摘要：Hiv protease inhibitor can ...
Protease Inhibitors (PIs) These drugs block a protein that infected cells need to put together new HIV virus particles. Atazanavir or ATV (Reyataz) Darunavir or DRV (Prezista) Lopinavir + ritonavir, or LPV/r (Kaletra) Ritonaviror RTV (Norvir) ...
HIV protease inhibitors, useful for the treatment of AIDS THE PRESENT INVENTION REFERS TO NEW FORMULA I HIV INHIBITORS, PHARMACEUTICAL FORMS CONTAINING THESE COMPOUNDS AND METHODS OF TREATMENT AND / OR PREVENTION ... JE Fritz,M Hammond,S Kaldor 被引量: 0发表: 1993年 Design of HIV-Protease In...
HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent Transposition of the pyridyl nitrogen from the P3 substituent to the P1′ substituent in HIV-1 protease inhibitors (PI) affords compounds such as 3 with an......
enantioselective preparation and their use as intermediates for the synthesis of peptidic agents, in particular for renin inhibitors and HIV protease inhibitors... J Mittendorf,W Hartwig 被引量: 0发表: 1993年 Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential ...
Identification of Novel HIV 1- Protease Inhibitors: Application of Ligand and Structure Based Pharmacophore Mapping and Virtual Screening. PLoS One. 2012;7(11): 关于浦华 深圳浦华系统技术有限公司专注于能源化工和生命科学领域信息化的开拓与创新。浦华作为达索系统(Dassault Systèmes)的合作伙伴,基于达索系统...
In the second phase of our study, a structure-based five feature pharmacophore hypothesis was generated which signifies the importance of hydrogen bond donor, hydrogen bond acceptors and hydrophobic interaction between the HIV-1 protease enzyme and its inhibitors. This work has taken a significant ...