PIs:Protease Inhibitors,即蛋白酶抑制剂,这些药物通过阻止病毒蛋白酶的活性来抑制HIV-1。 INSTIs:Integrase Strand Transfer Inhibitors,即整合酶链转移抑制剂,是一类抗HIV药物,通过抑制整合酶来阻止病毒整合到宿主DNA中。 INBIs:Integrase Binding Inhibitors,即整合酶结合抑制剂,这些药物通过不同的机制抑制整合酶活性。
Although protease acts at the last step of the virus life cycle, protease inhibitors were discovered shortly after nucleoside reverse transcriptase inhibitors. The era of HIV protease inhibitor drugs began in 1996 with the i...
The protease encoded within the pol gene of human immunodeficiency virus (HIV) is essential for maturation of the newly budded virion to an infectious viral particle. For this reason, inhibitors of the HIV protease have been developed as possible drugs for treatment of acquired immunodeficiency ...
目前,批准用于治疗 AIDS 的抗病毒药物主要有黏附抑制剂(attachment inhibitors,AIs)、逆转录酶抑制剂(reverse transcriptase inhibitors,RTIs)、蛋白酶抑制剂(protease inhibitors,PIs)、整合酶抑制剂(integrase inhibitors,INs)、融合抑制...
in blood serum, in which we use combination of three to five drugs targeting different stages of replication cycle of HIV. HIV-protease inhibitors are the indispensable part of this therapy. There is a great need of screening of anti-HIV agents from chemical as well as natural resources. But...
Contraindicated statin use in people living with HIV have declined between 2007 and 2014 because of less frequent preions for HIV protease inhibitors. 由于HIV蛋白酶抑制剂的处方使用频率较低,在2007年至2014年期间,HIV感染者中禁止使用他汀类药物的情况有所减少。
[17] Bhagwat P, Ofotokun I, McComsey GA,et al. Changes in waist circumference in HIV-infectedindividuals initiating a raltegravir or protease inhibitor regimen: efects of sex and race[J]. Open Forum InfectDis, 2018, 5(11):ofy201. ...
Human immunodeficiency virus 1 (HIV-1) protease inhibitors have dramatically reduced the morbidity and mortality due to HIV-1 infection. However, most of these antiretrovirals are also potent inhibitors (and occasionally inducers) of hepatic and intestinal cytochrome P450 systems and, therefore, have ...
HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because these drugs cause toxicities that can be associated with inhibition of Akt, an emerging target in cancer, we assessed the potential of HIV protease inhibitors as anticancer agents. Experimental Design: HIV ...
Protease Inhibitors (PIs) These drugs block a protein that infected cells need to put together new HIV virus particles. Atazanavir or ATV (Reyataz) Darunavir or DRV (Prezista) Lopinavir + ritonavir, or LPV/r (Kaletra) Ritonaviror RTV (Norvir) ...