Atazanvirand fosamprenavir are two recently approved HIV-1 protease inhibitors.Atazanavir,( BMS-232632)2-5: is a type of antiretroviral agent called a protease inhibitor (PI). It blocks protease, a protein that HIV needs to make more copies of it. It is indicated in combination with other ...
目前,批准用于治疗 AIDS 的抗病毒药物主要有黏附抑制剂(attachment inhibitors,AIs)、逆转录酶抑制剂(reverse transcriptase inhibitors,RTIs)、蛋白酶抑制剂(protease inhibitors,PIs)、整合酶抑制剂(integrase inhibitors,INs)、融合抑制...
导读 近日美国学者设计合成了一系列含双环恶唑烷酮骨架作为P2配体的HIV-1蛋白酶抑制剂,并讨论了它们的构效关系。相关研究发表于J. Med. Chem.,题为“Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxaz-olidinone Scaffold as the P2 Ligands : Structure -Activity Studies and ...
2. WHO. HIV fact sheet[EB/OL].https://www.who.int/zh/news-room/fact-sheets/detail/hiv-aids2019; 3. Research progress in the development of HIV-1 protease inhibitors( 2015 - 2019),2020.
HIV-1 PROTEASE INHIBITORS 优质文献 相似文献 参考文献The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable...
These features of the protease inhibitors might enhance the activity of retinoids. To explore this hypothesis, myeloid leukemia cells were cultured with all-trans retinoic acid (ATRA) either alone or in combination with the HIV-1 protease inhibitors indinavir, ritonavir, and saquinavir. Consistent ...
随着全面抗病毒治疗(ART)范围的逐步扩大,艾滋病病毒(HIV)耐药也逐渐地出现,而且呈现地区不平衡的特点,这直接导致了ART失败率增高以及地区间治疗较大的差异。HIV在宿主体内复制过程中离不开反转录酶(reverse transcriptase),蛋白酶(protease)和整合酶(integrase)。
Identification of Novel HIV 1- Protease Inhibitors: Application of Ligand and Structure Based Pharmacophore Mapping and Virtual Screening. PLoS One. 2012;7(11): 关于浦华 深圳浦华系统技术有限公司专注于能源化工和生命科学领域信息化的开拓与创新。浦华作为达索系统(Dassault Systèmes)的合作伙伴,基于达索系统...
近日美国学者设计合成了一系列含双环恶唑烷酮骨架作为P2配体的HIV-1蛋白酶抑制剂,并讨论了它们的构效关系。相关研究发表于J. Med. Chem.,题为“Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxaz-olidinone Scaffold as the P2 Ligands : Structure -Activity Studies and Biolog...
HIV-1 protease inhibitors principally target HIV-1 protease and inhibit its activities to make HIV-1 produce immature and non-infectious particles in the infectious cell, then HIV can not assemble itself normally and will be inhibited. HIV-1蛋白酶抑制剂主要抑制HIV-1蛋白酶的活性,使HIV-1在被感...