HIV protease inhibitors useful for the treatment of aidsA-G-B-B-JDesolms S. JaneHuff Joel R.Vacca Joseph P.Sigal Irving S.Darke Paul L.Young Steven D.
In the last few years, targeted antiviral drugs, such as protease inhibitors, have had an impressive effect on HIV-related morbidity and mortality. ... Richard,B,Pollard - 《American Journal of Medicine》 被引量: 29发表: 1999年 Attacking AIDS With a `Cocktail' Therapy. Reports on the tripl...
Presents information on a study which showed that for five HIV-1 PR mutations the mutant/wild-type ratio of Ki values and antiviral resistance have a low c... Klabe,M Ronald,Bacheler,... - 《Biochemistry》 被引量: 128发表: 1998年 HIV-1 protease inhibitors. A review for clinicians. The...
Other ideas for treatments include using protease inhibitors to kill the virus, or stopping it from binding to the ACE2 receptors on human cells. Michele Cohen Marill, WIRED, 28 Apr. 2020 The challenges that remain By the late 1990s, the availability of protease inhibitors led AIDS death rates...
The immunodeficiency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. In a JCI study scientists examine whether protease inhibitors (Pis) can inhibit cell death in vivo and the mechanisms involved. In three relevant mouse models HIV PIs block programmed ce...
Protease inhibitors show promise in HIV infection. (cover story) Recounts evidence that a new protease inhibitor still under investigation can prolong life and reduce complications in AIDS patients, as was reported at th... Nelson,Harry - 《Lancet》...
Accordingly, specific, exogenous inhibition of the HIV-1 protease is thought to be a viable approach for the development of novel therapeutics for the treatment of AIDS. Indeed, this hypothesis has been validated in virally-infected cell culture with synthetic inhibitors of HIV-1 protease. This ...
Factors involved in the cerebral transport of HIV protease inhibitors; Interactions of P-glycoprotein and IV protease inhibitors; Interactions of multidrug resistance associated proteins and HIV protease inhibitors.关键词: efflux protein HIV protease inhibitor P-glycoprotein ...
Achieving targeted antiretroviral (ARV) plasma concentrations during long-term treatment in human immunodeficiency virus (HIV)-infected patients with substance-related disorders (SRDs) may be challenging due to a number of factors, including medication adherence, coinfection with hepatitis B or C virus,...
PROTEASE INHIBITORS HIV THAT MAY BE OBTAINED THROUGH CHEMISTRY SYNTHESIS AND BIOLOGICAL ACTIVITY BLOCKING PROTEASE HIV enzyme, causing HIV virus reproduction ends. These compounds as well as pharmaceutical compositions containing these compounds and possibly other anti-viral agents as ingredients, are therefo...