drug levels of Nelfinavir (10 μ M).Conclusions: Nelfinavir is a unique drug in the class of HIV-PI, which leads not only to the induction of ER stress and inhibition of AKT-phosphorylation, but also to proteasome inhibition of all active subunits in intact cells at therapeutic drug levels...
1 nucleoside-reverse transcriptase inhibitor (NRTI) + 1 nucleotide-reverse transcriptase inhibitor (NRTI) drug, often referred to as "dual nuc" (pronounced dual nook), plus 1 protease inhibitor (PI), OR 1 non-nucleoside reverse transcriptase inhibitor (NNRTI, "non-nuc"), OR 1 integrase strand...
Immunoliposomes loaded with the protease inhibitor indinavir and surface modified with anti-HLA-DR were found to effectively bind to HIV infected cells and deliver the anti-retroviral drug leading to a significant reduction in the viral load [44]. In another study, the biodistribution of anti-HLA...
gp120 Attachment Inhibitor This class of drug has just one medication —fostemsavir, or FTR (Rukobia).It targets the glycoprotein 120 on the surface of the virus. This stops the virus from being able to attach itself to the CD4 T cells of your body's immune system. It is for adults ...
HIV treatment includes multiple drugs. If you’re taking a protease inhibitor for your HIV, a booster drug will help it work better. Learn more about how it works and what to watch for.
It has been suggested that the inhibitors designed on the APV template may be less susceptible to drug resistance. (King, N. M. et al. J. Virol. 2004, 78, 12012-12021.) Protease inhibitor TMC114 2, structurally similar to 1, has been recently shown to possess very potent in vitro ...
ReutersKaiser Daily HIV/AIDS Report
Varney pioneered the use of protein-structure based drug design at Agouron Pharmaceuticals. This innovative approach led to the discovery and market approval of HIV protease inhibitor, Viracept®. After Agouron's acquisition by Warner Lambert and subsequently by Pfizer, he served as Vice President...
The present invention features compounds that are HIV protease inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection
co-administered drug (as HIV protease inhibiting compound, an HIV (non)nucleoside/nucleotide inhibitor of reverse transcriptase, capsid polymerization inhibitor, interferon, ribavirin analog) by inhibiting cytochrome P450 monooxygenase; ureido- or amido-amine derivatives; side effect reductionUS 7939553 B2 ...