B461 HIV Protease Inhibitors Are Efficacious In Vivo in a Myeloma Mouse Modeldoi:10.1016/S1557-9190(11)70743-0B ArnulfI KarlinC BonoS LabaumeJP FermandJC BorieClinical Lymphoma and Myeloma
HIV PROTEASE INHIBITORS 专利名称：HIV PROTEASE INHIBITORS 发明人：ALBIZATI, KIM, F.,REICH, SIEGFRIED,VARNEY, MICHAEL, D.,ZHANG, KANYIN,E.,KOBAYASHI, TAKUO 申请号：US9804735 申请日：19980312 公开号：WO9840357A3 公开日：19981126 专利内容由知识产权出版社提供 摘要：HIV protease inhibitors, obtainable...
HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma. Nat Med. 2002;8:225–32. Article CAS PubMed Google Scholar Hernández S, Catalán-García M, Morén C, García-Otero L, López M, Guitart-Mampel M, et al. Placental Mitochondrial Toxicity...
Structure-based design and synthesis of novel HIV protease inhibitors are described. The inhibitors are designed specifically to interact with the backbone of HIV protease active site to combat drug resistance. Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral potency. Furthermor...
蛋白酶抑制剂(Protease inhibitor,PIs)是肽类的化合物,是开发的第二类抗逆转录病毒药物,广泛用于治疗HIV / AIDS和丙型肝炎(HCV)。蛋白酶抑制剂通过选择性结合病毒蛋白酶(例如HIV-1特异天冬酰蛋白酶),并阻止产生感染性病毒颗粒所必需的蛋白质前体的蛋白水解裂解,来阻止病毒复制。
Through pilot screening of a collection of 130 known protease inhibitors, the AlphaLISA assay confirmed all 11 HIV protease inhibitors in the library capable of suppressing precursor autoprocessing at low micromolar concentrations. Meanwhile, other protease inhibitors had no impact on precursor auto...
HIV protease inhibitors useful for the treatment of aids Compounds of the form wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in ...
目前,批准用于治疗 AIDS 的抗病毒药物主要有黏附抑制剂(attachment inhibitors,AIs)、逆转录酶抑制剂(reverse transcriptase inhibitors,RTIs)、蛋白酶抑制剂(protease inhibitors,PIs)、整合酶抑制剂(integrase inhibitors,INs)、融合抑制...
Protease Inhibitors (PIs) These drugs block a protein that infected cells need to put together new HIV virus particles. Atazanavir or ATV (Reyataz) Darunavir or DRV (Prezista) Lopinavir + ritonavir, or LPV/r (Kaletra) Ritonaviror RTV (Norvir) ...
An antiretroviral drug used to treat HIV infection; Kaletra is a combination of lopinavir and ritonavir, two drugs that are protease inhibitors (PIs) Kaposi`s sarcoma - 卡波氏肉瘤 Cancer of the blood vessels caused by a herpes virus; symptoms include red, pink or purple spots on the skin or...