Histone-Lysine N-MethyltransferaseArginineLysineDNA-Binding ProteinsEukaryotic genomes are organized into active (euchromatic) and inactive (heterochromatic) chromatin domains. Post-translational modifications o
Histone proteins H2A, H2B, H3, and H4 are methylated at lysine (K) and/or arginine (R) residues along their N-terminal tails by methyltransferase enzymes (green). These methyl marks can be subsequently removed by demethylase enzymes (pink). All human histone methyltransferases and demethylases ...
histone methyltransferase; HKMT, histone lysine methyltransferase; IDH, isocitrate dehydrogenases; KDM, lysine demethylase; α-KG, α-ketoglutarate; MAO, monoamine oxidase; MLL, mixed lineage leukemia; LSD1, lysine-specific demethylase 1; PHF, plant homeodomain finger; PRC2, polycomb repressive complex...
Darker shade indicates mono-, di-, and trimethylation by HMTs or demethylation of di- and trimethylated lysine residues by HDMs. PRMTs proteins, characterized by a common catalytic methyltransferase domain and unique N-terminal and C-terminal regions, are divided into three different classes: type...
Retinoblastoma Binding Protein 5 (RBBP5), ASH2 Like, Histone Lysine Methyltransferase Complex Subunit (ASH2L), in order to effectively complete the methyla- tion modification process [22]. MLL1 can participate in all methylation forms of H3K4, and its gene translocation rearrangement can lead to...
(NSD1, NSD2/WHSC1, ASH1L, and SET2/SETD2) (Table1). DOT1L includes a seven-beta-strand domain (7βS) instead of the SET domain, which contains a lysine methyltransferase activity toward H3K79.52,53Histone lysine demethylation is achieved by two conserved families of KDMs employing ...
We found that H3Q5his, in contrast to H3Q5ser, inhibits the binding of WDR5, a core member of histone H3 Lys4 (H3K4) methyltransferase complexes, thereby antagonizing methyltransferase activities on H3K4. Taken together, these data elucidate a mechanism through which a single chromatin regulatory ...
Methylation is operated by histone methyltransferases enzymes, histone-lysine N- methyltransferase and histone-arginine N-methyltransferase: both catalyze the transfer of one to three methyl groups from the co-factor S-adenosyl methionine to lysine and arginine residues of histone proteins. Methylation of...
In particular, the nuclear receptor-binding SET domain (NSD)2 family of histone lysine methyltransferase enzymes, NSD1, NSD2/WHSC1/MMSET, and NSD3/WHSC1L1, have all been implicated as cancer therapeutic targets (1). The catalytic SET domain (Suppressor of variegation, Enhancer of zeste, ...
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16(8):919–932 Article PubMed ...