Histone-lysine N-methyltransferase ash1 is a Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. 应用类型 Immunolocalization (IL), Chromatin Immunoprecipitation (ChIP) ...
In mammals, the methyltransferases responsible for H3K36 methylation include nuclear receptor binding SET domain protein 1 (NSD1)/KMT3B, NSD2/KMT3G, NSD3/KMT3F, ASH1-like histone lysine methyltransferase (ASH1L)/KMT2H, SMYD2/KMT3C, SET domain-containing protein 2 (SETD2)/KMT3A, SETD3 and...
Histone-Lysine N-MethyltransferaseLysineDNA-Binding ProteinsSaccharomyces cerevisiae ProteinsHistonesTranscription FactorsHistone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6. Mutually ...
during ES celldifferentiation, ASH2L and WDR5 levels are down-regulated whereas MLL1 and MLL3are up-regulated [47,121]. In addition, some H3K4 methyltransferase complexes may havenon-redundant cellular function by regulating their unique target genes in acell type-specific manner, as mentioned ...
H. Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells. Biochem Biophys Res Commun 446, 113–118, doi: 10.1016/j.bbrc.2014.02.061 (2014). 34. Hughes, A. L. & Gottschling, D. E. An early age increase in vacuolar pH limits mitochondrial function and ...
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase Nature, 416 (2002), pp. 556-560 View in ScopusGoogle Scholar Jenuwein, 2006 T. Jenuwein The epigenetic magic of histone lysine methylation FEBS J., 273 (2006), pp. 3121-3135 CrossrefView in ScopusGoogle Scholar ...
Background: The nuclear receptor binding SET domain (NSD) protein is a family of three histone-lysine N-methyltransferase (HMTase), NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 that are critical in maintaining the chromatin integrity. NSD1 m... ED Luccio,M Morishita - 《Cancer Research》 被...
H3K27me3 is a hallmark of transcriptional repression. The EZH2 (enhancer-of-zest homolog 2) subunit (also known as KMT6A) within PRC2 (polycomb repressive complex 2) complex, an evolutionarily conserved class of polycomb group proteins, is an H3K27 methyltransferase153responsible for all three...
H3K79me2: histone H3 lysine 79 dimethyl HPC: hippocampus ID: intellectual disability IEG: immediate early gene JmjC: JumonjiC KDM: lysine demethylase KMT: lysine methyltransferase LC–MS/MS: liquid chromatography–tandem mass spectrometry mESC: ...
展开 关键词: Animals Lysine Histone-Lysine N-Methyltransferase DNA Helicases Transcription Factors RNA Polymerase II DNA-Binding Proteins Homeodomain Proteins Drosophila Proteins Chromosomal Proteins, Non-Histone DOI: 10.1371/journal.pgen.1000217 被引量: 465 年份...