In mammals, the methyltransferases responsible for H3K36 methylation include nuclear receptor binding SET domain protein 1 (NSD1)/KMT3B, NSD2/KMT3G, NSD3/KMT3F, ASH1-like histone lysine methyltransferase (ASH1L)/KMT2H, SMYD2/KMT3C, SET domain-containing protein 2 (SETD2)/KMT3A, SETD3 and...
H3K9 methyltransferase inhibitors may have promising applications as novel therapies for chronic heart failure by reducing excess heterochromati- nization at repetitive regions in the genome and restoring heart function. Discussion In this study, we demonstrated that the histone H3K9 methyltransferase ...
Intriguingly,in vitrohistone methyltransferase assays have demonstrated that Dot1 proteins preferentially methylate nucleosomal substrates rather than free histone H3.214,220,221In addition, it has been shown that a positively charged region within human DOT1L (amino-acid residues 390–407) is required f...
UDP-glycosyltransferase 73C4, and fructose-bisphosphate aldolase), response to stimulus and stress (GPX, Hsp70-Hsp90 organizing protein 2, universal stress protein PHOS32 and PHOS34, autophagy-related protein 11, GDSL esterase/lipase, and putative methyltransferase DDB_G0268948) and other biological ...
[53–55]. In addition to common core subunits, there are unique subunits inthe individual H3K4 methyltransferase complexes: WDR82 and CXXC finger protein 1(CFP1) in the SET1 complex; Multiple endocrine neoplasia type 1 (MENIN) and PC4and SFRS1-interacting protein 1 (PSIP1) in MLL1 and...
The first study to implicate a specific histone methyltransferase in maintaining H3K4me3 broad domains was published recently by Dhar et al., showing that brain-specific loss of KMT2D led to decreased H3K4me3 levels at H3K4me3 broad domains and decreased expression of marked genes, with no apparent...
Additionally, in support of a post-transcriptional function, the yeast SET1 H3K4 methyltransferase responsible for H3K4me3 modification is recruited to the +300 bp region of genes after transcription initiation in yeast [48]. Elevated H3K4me3 levels occurring on genes with increased transcript production...
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex Cell, 111 (2002), pp. 197-208 View in ScopusGoogle Scholar [18] L. Kaustov, H. Ouyang, M. Amaya, A. Lemak, N. Nady, S. Duan, G.A. Wasney, Z. Li, M. Vedadi, M. Schapira, J. Min, C.H. Ar...
and each complex contains one of the six H3K4‐methyltransferase, Set1α or its paralog Set1β, MLL1 or its paralog MLL2 (aka WBP7), or MLL3 (aka KMT2C) or its paralog MLL4 (aka KMT2D)11,12. We have identified the first two mammalian Set1‐like complexes, MLL3- and MLL4-comple...
f Metaprofile plot of H3K9me2 (left) and H3K9me3 (right) ChIP-seq signal at TSS ± 5 kb of bivalent genes (n = 4117). g Histone methyltransferase assays of PRC2 in the presence of chromatin reconstituted using different H3 variants and H3K9 modifications. In all cases, “...