Histone lysine methylation is predominantly catalyzed by a group of lysine methyltransferases (KMTs) harboring a catalytic SET domain named after the first three identified proteins having this domain in Drosophila: suppressor of variegation [49], enhancer of zeste homolog 2 (EZH2), and Tr...
Histone lysine methyltransferasesHistone methylationSpermatogenesisMale infertilityTesticular agingSpermatogenesis is finely regulated by histone methylation, which is crucial for regulating gene expression and chromatin remodeling. Functional studies have demonstrated that the histone lysine methyltransferases (KMTs) ...
Biomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from ‐adenosylmethionine (AdoMet) cosubstrate to lysine residues in histones and other proteins. Herein, experimental and computational investigations on human KMT‐catalyzed ethylation of histone ...
aHistone (lysine) methyltransferases (KMTs), histone (lysine) demethylases (KDMs), histone deubiquitinase, and histone acetyltransferases (HATs) modify histone 3 posttranslaltionally 组蛋白 (赖氨酸) methyltransferases (KMTs),组蛋白 (赖氨酸) demethylases (KDMs),组蛋白deubiquitinase和组蛋白乙酰基移转...
组蛋白甲基转移酶(Histone methyltransferases,HMTs)将S-腺苷甲硫氨酸(Sadenosylmethionine,AdoMet/SAM)上的甲基转移到组蛋白赖氨酸或精氨酸位点上以完成对组蛋白的甲基化修饰(图4)。HMTs分为两类:赖氨酸甲基转移酶(Histone lysine methyltransferase,HKMTs)和精氨酸甲基转移酶(Protein arginine methyltrans ferases,PRMT...
The methylation status of histones at different lysine residues is controlled by the reciprocal actions of specific histone lysine modifiers: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs) (Fig.1). The different activities of KMTs and KDMs in a given cellular context...
According to the amino acids catalyzed by this enzyme, HMTs are divided into two families: histone lysine methyltransferases (KMTs) and protein arginine methyltransferases (PRMTs). The KMTs family includes EZH2, G9a, DOT1L and SETD2; and the PRMTs family has 9 members from PRMT1–9 in ...
Heart disease has been linked to deregulated histone lysine methylation, and lysine-specific methyltransferases (KMTs) are overrepresented, i.e., more numerous than expected by chance, among the genes with variants associated with congenital heart disease. This review outlines the available evidence to...
The role of histone lysine methyltransferases (KMTs) is to add methyl groups. Thus, they function as ‘writers’ of the histone code, whereas histone lysine demethylases (KDMs) are known as ‘erasers’ of methyl groups (Figure 2) [33]. Catalyzed by methyltransferase, methylation leads to add...
The methylation patterns on histones are tightly controlled by lysine methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability. KMTs are enzymes that transfer a methyl group to a specific lysine residue on a histone, whereas KDMs facilitate methyl group removal...