(PDC); it can also be generated from fatty acid β-oxidation and amino acids andketone bodies(Sivanand et al., 2018). The levels of acetyl-CoA are affected by the catabolic/anabolic state of the cell and affect globalhistoneacetylation levels by serving as acofactorfor HATs (Sivanand et ...
G. Allfrey, "Chemical studies of histone acetylation. The distribution of epsilon- N-acetyllysine in calf thymus histones.," Journal of Biological Chemistry, vol. 243, no. 24, pp. 6361-6366, 1968.G. Vidali, E. L. Gershey, and V. G. Allfrey, "Chemical studies of histone acetylation...
Using M1 macrophages that have been exposed to bacteria as a model system, we show that histone lactylation has different temporal dynamics from acetylation. In the late phase of M1 macrophage polarization, increased histone lactylation induces homeostatic genes that are involved in wound healing, ...
Interactions between bacteria and fungi have great environmental, medical, and agricultural importance, but the molecular mechanisms are largely unknown. Here, we study the interactions between the bacterium Pseudomonas piscium, from the wheat head micro
Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation The modification of histone N-terminal tails by acetylation or deacetylation can alter the interaction between histones and DNA, and thus regulate gene... Dong-In Sinn a b,...
transfection, the expression level of periodical inhibitory protein p21 of a specific induced cell is improved; and the combination of the bonding histone deacetylase 1 and the p21 is restrained to increase the acetylation modification of the p21 protein and restrain degradation of the p21 protein. ...
Ren et al; Simultaneous metabolic labeling of cells with multiple amino acids: localization and dynamics of histone acetylation and methylation, Proteomics: Clinical Applications; Jan. 2007; vol. 1, No. 1, pp. 130-142.C. Ren, S. Liu, K. Ghoshal, P.H. Hsu, S.T. Jacob, G. Marcucci...
Acetylation Butyric Acid Programmed Cell Death Histone Deacetylase Inhibitor Gene Expression Short Chain Fatty Acid Histone View all Topics Featured Authors Adcock, Ian M. National Heart and Lung Institute, London, United Kingdom Citations 44,854 h-index 114 Publications 153 Weichert, Wilko Klinikum...
amino acid sequence of the N-terminal tail of histone H4 is strikingly similar to that of H2A.Z.1/2 proteins (Supplementary Fig.1b), H4 acetylation was also explored (Supplementary Fig.1c). While more complex in its regulation, increased expression of combinatorial H4 acetylation (e.g., ...
Histone tail acetylation is a key epigenetic marker that tends to open chromatin folding and activate transcription. Despite intensive studies, precise roles of individual lysine acetylation in chromatin folding have only been poorly understood. Here, we revealed structural dynamics of tri-nucleosomes wit...