Synonyms Cav1.1鈥 4 "long-lasting" type (L type) ; Cav2.1 "Purkinje" type (P/Q type) ; Cav2.2 "non-L type" (N type) ; Cav2.3 "residual" type (R type) ; High-voltage-gated calcium channels Definition Calcium channels are one of the oldest members of the voltage-gated channel ...
Gonzalez-Gutierrez G, Miranda-Laferte E, Contreras G, Neely A, Hidalgo P (2010) Swapping the I-II intracellular linker between L-type Ca V 1.2 and R-type Ca V 2.3 high-voltage gated calcium channels exchanges activation attributes. Channels (Austin) 4:42–50...
Calcium entry through voltage-gated calcium channels (VGCC) initiates diverse cellular functions. VGCC pore-forming subunit (CaVα1) contains four homology repeats, each encompassing a voltage sensor and a pore domain. Three main classes of CaVα1 subunits have been described, CaV1, CaV2 and...
Calcium influx into cardiac myocytes via voltage-gated Ca channels is a key step in initiating the contractile response. During prolonged depolarizations, toxic Ca2+ overload is prevented by channel inactivation occurring through two different processes identified by their primary trigger: voltage or int...
Such a breadth of signaling variety results from an intricate combination of underlying variables66, including the field stimulation that can excite various parts of the neuron76, natural biological complexity involving the relative concentration and location of membrane voltage-gated calcium channels77,78...
High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury Changes in ion channel function and expression are characteristic of neuropathic pain. Voltage-gated calcium channels (VGCCs) are integral for neurotransmi... SS Murali,IA...
Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca2+ channel α2δ-1 auxiliary subunit Voltage-gated calcium (CaV) channels are transmembrane proteins that form Ca2+-selective pores gated by depolarization and are essential regulators of the ... A Cald...
We have cloned two splice variants of the human homolog of the α1A subunit of voltage-gated Ca2+ channels. The sequences of human α1A-1 and α1A-2 code for proteins of 2510 and 2662 amino acids, respectively. Human α1A-2α2bδβ1b Ca2+ channels expressed in HEK293 cells activa...
B. Crystal structure of the calcium release-activated calcium channel Orai. Science 338, 1308–1313 (2012). 11. Tang, L. et al. Structural basis for Ca2 þ selectivity of a voltage-gated calcium channel. Nature 505, 56–61 (2014). 12. Moomaw, A. S. & Maguire, M. E. The ...
The impact of splice isoforms on voltage-gated calcium channel α1 subunits J. Physiol., 554 (2004), pp. 609-619 View in ScopusGoogle Scholar 3 D.R. Abernethy, N.M. Soldatov Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets J. Pharmac...