High fat diet induces brain insulin resistance and cognitive impairment in mice. Biochim Biophys Acta. 2017;1863:499-508.Kothari V, Luo Y, Tornabene T, O'Neill AM, Greene MW, Geetha T, Babu JR (2017) High fat diet induces brain insulin resistance and cognitive impairment in mice. ...
High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect brain synaptic plasticity through impairment of insulin-sensitive processes underlying neuronal survival, learning, and memory. The experimental model consisted of 3 month-old C57BL/6J mice fed either a normal...
Insulin resistance, concomitant with substantial weight gain and obesity, can be induced by feeding rodents a high fat diet (HFD) for a period of many weeks or months4,5,6,7. However, insulin resistance is detectable in rodents after only one to three weeks of a HFD, prior to major incr...
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload.: Insulin resistance
This study investigated immunohistochemical changes in expressions of OXA, its receptor OX1R in pancreas and AdipoR1 in skeletal muscle with a high fat diet (HFD)-induced insulin resistance (IR). Standard 45% fat and 60% fat diets were administered to Wistar rats for 3 and 8 w. OXA ...
A high-fat (HF) diet causes insulin resistance. To characterize this type of insulin resistance, autophosphorylation of the insulin receptor (IR) in vitro and in vivo, phosphorylation of its endogenous substrates (pp190, pp175), and the amount of glucose transporters (GLUT-2, GLUT-4) were ...
Our aim in this study was to address whether diet-induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Methods We fed Watanabe heritable hyperlipidemic (WHHL) rabbits with a high-fructose and high-fat diet (HFFD) with ...
After consuming high-fat diet (HFD), ROS production in rat liver was increased dramatically [1], which preceded the onset of insulin resistance [2], the key etiological defect that defines type 2 diabetes. There are a number of reported causes for HFD to induce oxidative stress. However, ...
Despite a significant pro-inflammatory effect, estrogens protect from the occurrence of high-fat diet-induced insulin resistance and glucose intolerance th
IR and the Insulin Resistance occurs in muscle tissue,liver tissue and the adipose tissue of insulin induced by High-fat diet are generalized.The conclusion is that the long-term high-fat diet can alter the body's glucose and lipid metabolism significantly,thus,the insulin resistance is induced...