miRNA-150_R-1 mediates the HIF-1/ErbB signaling pathway to regulate the adhesion of endometrial epithelial cells in cows experiencing retained placenta. Front Vet Sci 2022, 9: 1037880. 11. Park M, Hong SH, Park SH, Kim YS, Yang SC, Kim HR, Noh S, Na S, Lee HK, Lim HJ, Lyu SW...
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 •381种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制: 364个化...
2020年6月,阎骅主任医师在《HAEMATOLOGICA》杂志发表题名为“Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy”——低氧诱导的长链非编码RNA DARS-AS1通过调节RBM39的稳定性促进多发...
Baimai Ointment relieves chronic pain induced by chronic compression of dorsal root ganglion in rats by regulating neuroactive ligand-receptor interaction and HIF-1 signaling pathway 引用 收藏 分享 摘要 具“舒筋活络”核心功效的白脉软膏临床干预疼痛、痉挛、僵硬等症状的白脉病疗效显著,但其药效学特点及...
during VC, exploring the role of HIF-1α-VEGFA-Notch1 signaling pathway in VC, further providing the new strategies for the study of the specific mecha- nism and clinical prevention and treatment of VC in CKD. Methods : 60 Spra- gue-Dawley (SD) rats were randomly divided into Control ...
HIF-1 related signaling pathway and its role in autoimmune diseases 在线阅读 下载PDF 引用 收藏 分享 摘要 自身免疫性疾病(AID)是一类由自身抗原引起自身组织损伤的疾病。目前治疗AID仍以对症治疗和控制病情进展的药物为主,缺乏有效治疗措施,从而造成其致死率较高、治愈率较低的现状。因此对AID发病机制的详细...
Renal fibrosis is a common outcome of chronic kidney diseases and glycolysis drives the development of renal fibrosis in damaged kidneys. Ulinastatin (UTI) is a broad-spectrum protease inhibitor with anti-inflammatory and antioxidant properties with anti
中文摘要 虽然已经证明低氧信号在许多细胞过程中发挥作用,但它在代谢相关的细胞外基质(ECM)组织和肌肉骨骼损伤后细胞命运的下游过程中的作用尚未确定。异位骨化(HO)是一种使人衰弱的状况,其中异常的骨形成发生在骨骼以外的组织中。已经显示低氧和低氧诱导因子1α(HIF-1α)的激活促进了HO。然而,HIF-1α途径在间充质...
语种:中文 中文关键词:脓毒症;肠道上皮损伤;低氧诱导因子1α;mTOR/P70S6K信号通路 外文关键词:Sepsis;Intestinal epithelial injury;Hypoxia-inducible factor-1α;mTOR/P70S6K signaling pathway 中文摘要:目的:探讨缺氧诱导因子1α(hypoxia-inducible factor-1α,HIF-1α)在脂多糖(lipopolysaccharide,LPS)诱导的Caco-...
signalingpathway’S mechanismisnotelucidated.RNAiisa powerful tool tO inhibitthe targetgene expression bypost-transcriptional gene silencing. Vll ,;tE毒 博士学位论文 英文摘要 When 21bp small interference RNA(siRNA)is transfectedinto mammalian cells,sequence—specific ...