Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
HIF-1 related signaling pathway and its role in autoimmune diseases 在线阅读 下载PDF 引用 收藏 分享 摘要 自身免疫性疾病(AID)是一类由自身抗原引起自身组织损伤的疾病。目前治疗AID仍以对症治疗和控制病情进展的药物为主,缺乏有效治疗措施,从而造成其致死率较高、治愈率较低的现状。因此对AID发病机制的详细...
HIF-1α/VEGF signaling pathway is thought to play a dual role following SCI. In one hand, VEGF was demonstrated to be correlated with angiogenesis (protecting vascular endothelial cells, increasing blood vessel density and improving regional blood flow), neurogenesis (antiapoptotic, neurotrophic, ...
Signaling pathway of HIF-1α/VEGF regulates several important biologic pathways , including cell proliferation , angiogenesis , cell metabolism , anti-apoptosis and migration. In the present study , hypoxia plays a major role in tumor progression ( proliferation and metastasis ), therapy resistance ...
Wnt/-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast di... - 《Journal of Bone & Mineral Research》 被引量: 805发表: 2010年 The hypoxia-inducible factor α pathway couples angiogenesis to oste...
Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Activation of HIF-1α signaling has been observed in a series of cancers including gastric cancer. Moreover, a variety of oncogene...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.%缺氧诱导...
The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating diseases accompanied by H‑I. 展开 ...
中文摘要 虽然已经证明低氧信号在许多细胞过程中发挥作用,但它在代谢相关的细胞外基质(ECM)组织和肌肉骨骼损伤后细胞命运的下游过程中的作用尚未确定。异位骨化(HO)是一种使人衰弱的状况,其中异常的骨形成发生在骨骼以外的组织中。已经显示低氧和低氧诱导因子1α(HIF-1α)的激活促进了HO。然而,HIF-1α途径在间充质...