1 promotes the expression of hundreds of genes involved in cell autonomous and non-autonomous adaptations to hypoxia. Examples of genes and their functions are found in the diagram. HIF-α can be upregulated at the protein level via mTOR or at the mRNA level via STAT3 and NF-κB signaling....
英文名称 HIF-1 Signaling Pathway Compound Library 产品介绍 描述及优势 •443种HIF-1信号通路化合物的独特集合,用于高通量筛选(HTS)和高内涵筛选(HCS) •靶点包括HIF,HDAC,PI3K,MAPK,VHL等 •用于探索细胞氧感应的机制 •某些化合物已被FDA批准 •结构多样,具有药用活性且可渗透细胞 详细信息 配制...
HIF-1 signal pathway in cellular response to hypoxia 在线阅读 免费下载 引用 收藏 分享 摘要 低氧诱导因子(hypoxia inducible factor,HIF)由HIF-1α和HIF-1β两个亚基组成,在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激,以及某些病理过程中具有重要的作用。近10...展开更多 HIF-1 is ...
Signaling pathway of HIF-1α/VEGF regulates several important biologic pathways , including cell proliferation , angiogenesis , cell metabolism , anti-apoptosis and migration. In the present study , hypoxia plays a major role in tumor progression ( proliferation and metastasis ), therapy resistance ...
HIF-1α/VEGF signaling pathway is thought to play a dual role following SCI. In one hand, VEGF was demonstrated to be correlated with angiogenesis (protecting vascular endothelial cells, increasing blood vessel density and improving regional blood flow), neurogenesis (antiapoptotic, neurotrophic, ...
Gel shift assay showed that HIF-1 bound to the promoter sequence of Sost directly. These findings support our hypothesis that HIF-1α activates Sost expression. This study provides a novel molecular mechanism through which HIF-1α inhibits Wnt signaling in osteoblasts. 展开 ...
The effects of HIF‑1 on ischemic outcomes may be dependent on the H‑I duration, animal age and species. Thus, further investigation of the PI3K/Akt signaling pathway may provide further insights of the potential targets for treating diseases accompanied by H‑I. 展开 ...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.%缺氧诱导...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.%缺氧诱...
[6] Li T,Yu J,Chen R,Wu J,et al.Mycophenolate mofetil attenuates myocardial ial ischekia-reperfusion injury via regulation of the TLR4/NF-κB signaling pathway[J].Pharmazie,2014,69(11)850-855. [7] Burkitt MD,Williams JM,Duckworth CA,et al.Signaling mediated by the NF-κB subunits NF-...