抑制HIF-1α表达减少KOA大鼠滑膜NLRP3炎症小体活化.挥发油组与KOA组相比较,HIF-1α,NLRP3,caspase-1,ASC滑膜组织中的蛋白及基因表达以及血清中IL-1β,IL-18含量明显降低.结论(1)"三色散"挥发油分离出41种化学成分,鉴定了其中的30种;(2)KOA中,升高的HIF-1α诱导成纤维样滑膜细胞NLRP3炎症小体活化;(3)"...
值得注意的是,这些对子宫内膜HIF-1α水平起调节作用的药物主要在延缓子宫内膜异位症、子宫内膜癌症的进展和改善子宫内膜容受性等方面被研究,需要进一步体现以HIF-1α为核心的治疗策略对其它子宫内膜疾病的治疗价值。 图3 以HIF-1α为核心的治疗策略在子宫内膜疾病中的应用前景 四、讨论于展望 在本文中,作者全面回顾...
3. YANG H L, LIN P Y, VADIVALAGAN C, et al. Coenzyme Q0defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells[J]. Arch Toxicol...
TLR2的缺失抑制OVA诱导的焦亡和氧化应激 NLRP3炎症体参与气道炎症,其激活的一个重要后果是焦亡。炎症反应又可导致气道炎症的恶化。与这些报道一致,作者的研究表明,OVA致敏和处理明显诱导WT小鼠GSDMD-N、caspase-1(p20)和IL-1β(p17)的表达,而TLR2的缺失则降低了这些焦亡相关蛋白的表达(图2A)。一致的是,TLR2-/-...
Pyroptosis, also known as cellular inflammatory necrosis, is a type of caspase-1-dependent programmed cell death that mediated by NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory vesicles [12, 13]. The release of large amounts of inflammatory cytokines after the ...
In addition, repetitive ipsilateral SGB significantly restored the upregulated HIF-1α/NLRP3 signaling and the hyperactivated microglia and astrocytes following thalamic hemorrhage. The enhanced expression of pro-inflammatory cytokines and the oxidative stress in the peri-thalamic lesion sites were also ...
Zhu等[18]研究发现,ALP能通过激活Nrf2信号通路与抑制NLRP3信号通路在四氯化碳诱导的肝纤维化中发挥抗炎、抗氧化、抗血管生成的作用。自噬是真核细胞内通过消除受损细胞器和蛋白质,维持细胞稳态的生物学过程[19]。本研究结果说明,OA的进展与细胞自噬相关;ALP可促进IL-1β诱导的软骨细胞自噬和增殖并抑制凋亡。
Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis Article Open access 12 December 2023 PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis Article Open access 10 January 2022 Introduction...
Journal of NeuroVirology (2021) NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia Vanessa Lavallard David Cottet-Dumoulin Domenico Bosco Scientific Reports (2020)Download PDF Sections Figures References Abstract Introduction Results Discussion Methods Additional Informati...
NLRP3,GSDMD mRNA 与蛋白的表达.方法:1.真武汤复方化学成分鉴定超高效液相色谱仪联合高分辨质谱对真武汤复方化学成分进行鉴定.2.慢性肾脏病肾阳虚证大鼠模型的制备与分组58只雄性健康SPF级SD大鼠,适应性饲养1周,自由饮水,给予普通饲料.随机分为正常组10只,模型组48只即阿霉素组,阿霉素+氢化可的松组,真武汤组,温...