本研究中,通过LPS处理心肌细胞,焦亡相关蛋白如NLRP3、Caspase1和GSDMD表达量均显著增加,这表明LPS成功诱导心肌细胞发生焦亡。与LPS组相比,Car+LPS组心肌细胞NLRP3和GSDMD表达量显著降低,然而Caspase1表达量无显著变化,说明心肌肽可能通过非Cas...
Conclusions: DEX can alleviate myocardial I/R injury in diabetic mice by up-regulating HIF-1α, inhibiting the activation of NLRP3 inflammasome and reducing inflammatory response.丁佳慧吴建江程虎于文彬朱阔王江Progress in Modern Biomedicine
NLRP3炎症体参与气道炎症,其激活的一个重要后果是焦亡。炎症反应又可导致气道炎症的恶化。与这些报道一致,作者的研究表明,OVA致敏和处理明显诱导WT小鼠GSDMD-N、caspase-1(p20)和IL-1β(p17)的表达,而TLR2的缺失则降低了这些焦亡相关蛋白的表达(图2A)。一致的是,TLR2-/-小鼠的乳酸水平,即焦亡作用的标志性指标,...
14. Su P, Mao X, Ma J, Huang L, Yu L, Tang S, Zhuang M, Lu Z, Osafo KS, Ren Y, Wang X, Lin X, Huang L, Huang X, Braicu EI, Sehouli J, Sun P. ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer...
靳贺超等研究发现,高剂量当归补血汤可显著下调DKD大鼠TXNIP、NOD样受体热蛋白结构域相关蛋白3(NLRP3)、含半胱氨酸的天冬氨酸蛋白水解酶1(Caspase-1)、消皮素D(GSDMD)表达水平,减轻足细胞与肾组织细胞DNA损伤,明显改善肾功能。Zeng等研究发现,...
Pyroptosis, also known as cellular inflammatory necrosis, is a type of caspase-1-dependent programmed cell death that mediated by NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory vesicles [12, 13]. The release of large amounts of inflammatory cytokines after the ...
a well-established HIF-1α inhibitor, was used to confirm the regulatory effects of HIF-1α on the development of CPSP. MCC950, which is an NLRP3 selective inflammasome-specific inhibitor, was used to evaluate the roles of NLRP3 in the development of CPSP. Both YC-1 and MCC950 were dis...
Chen, Deng, Gan, Li, Huang, Lu, Wei, Su, Luo, Zou, Hong, Cao, Liu, Chi: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed). Qian, Li,...
Zhu等[18]研究发现,ALP能通过激活Nrf2信号通路与抑制NLRP3信号通路在四氯化碳诱导的肝纤维化中发挥抗炎、抗氧化、抗血管生成的作用。自噬是真核细胞内通过消除受损细胞器和蛋白质,维持细胞稳态的生物学过程[19]。本研究结果说明,OA的进展与细胞自噬相关;ALP可促进IL-1β诱导的软骨细胞自噬和增殖并抑制凋亡。
目的 探讨慢性阻塞性肺疾病急性发作期(AECOPD)患者血清甘胆酸(CG),N端B型脑钠肽(NT-pro BNP),缺氧诱导因子1α(HIF-1α)及核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)蛋白表达特点及意义.方法 选取我院2016年1月～2018年4月收治的COPD患者128例,其中急性加重期68例,稳定期60例,选取同期在我院门诊体检的健康...