Nrf2HIF-1 alphaSCUTELLARIA-BAICALENSISDOWN-REGULATIONNRF2RESISTANCECELLSRadiotherapy plays a crucial role in the multimodal treatment of breast cancer. However, radioresistance poses a significant challenge to its effectiveness, hindering successful cancer therapy. Emerging evidence indicates that Nrf2 and HIF-...
Nrf2 plays a key role in cellular antioxidant defences. Under basal conditions, Nrf2 is sequestered by Keap1 (Kelch-like ECH- associated protein) in the cytosol [19]. When challenged by oxi- dants, the complex disrupts and Nrf2 translocates to the nucleus where it leads to the transcription ...
Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and "cryptic targets" of transcription factors. Chin J Cancer. 2012 Sep;31(9):413-20.A. Ooi and K. A. Furge, "Fumarate hydratase inactivation in renal tumors: HIF1alpha, NRF2, and "cryptic targets" of transcription factors,...
SLC7A11 作为一类胱氨酸转运蛋白,其主要功能是 将细胞外的胱氨酸运输至细胞内,被核因子 E2 相 关因子 2(nuclear factor erythroid 2-related factor 2, Nrf2)[18],干扰素调节因子 1(interferon regulatory factor 1,IRF1)[17],p53[14],HIF-1α[17]等多种转录 因子调节. HIF-1α 是细胞对低氧或缺氧做出...
作者目前证明,OVA挑战诱导Nrf2及其相关抗氧化酶的表达上调:HO-1、SOD2、GPX1/2和TRX1在WT小鼠肺部的表达,而这种效应在OVA挑战的TLR2/-小鼠中减弱,但SOD2除外,它不受TLR2缺乏的影响(图2G和H)。有趣的是,GPX4(一种GSH依赖性过氧化物酶)的表达水平在受OVA刺激的WT小鼠中比对照小鼠低,但在受OVA刺激的TLR2-...
Whereas HIF-1 regulates the expression of genes important for the adaptation of cells to hypoxia, Nrf2 induces antioxidative enzymes such as thioredoxin 1 (Trx1), exerting a cytoprotective role. Here, we investigated the regulation and cross talk of HIF-1α and Nrf2 in intermittent hypoxia in ...
利用Western Blot法检测Nrf2和HIF-1α蛋白在肺组织的表达.结果表明:1)与对照组相比,模型组小鼠右心室压力明显增加,肺小动脉血管壁明显增厚,管腔变狭窄,右心室与体重的比值显著增加;2)与对照组相比,模型组小鼠肺组织HIF-1α蛋白表达明显增加,而Nrf2蛋白表达明显减少.研究结果意味着:HIF-1α与Nrf2在香烟烟雾法建立...
ROS trigger cellular adaptations through various signaling pathways and TFs, and kinase cascades such as the mitogen-activated protein kinases (MAPK), PI3K/Akt, and ASK1 are mentioned here [83,84]. Correspondingly, TFs that are activated by ROS comprise Nrf2, HIF-1α, AP-1, and NF-κB [...
应激相关分子NRF2和HO1蛋白表达下降,并伴随HIF1α表达上升;给予SGLT2i后NRF2与HIF1α表达恢复至正常水平;而下调NRF2基因表达则消除了SGLT2i对缺氧心肌细胞的保护作用.双荧光素酶报告基因检测发现,HIF1α可直接与NRF2基因启动子区域...
TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response Article Open access 24 June 2023 TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α Article Open access 16 December 2022 Data availability The time-series microarray ...