Consequently, the Nrf2/HIF-1 alpha pathway, along with the Nrf2- and HIF-1 alpha-dependent protective responses, were suppressed. Taken together, our findings demonstrate that WG can epigenetically regulate the Keap1 gene, inhibit the Nrf2/HIF-1 alpha pathway, induce apoptosis in breast cancer ...
ResearchpaperHydrogensulphideinducesHIF-1aandNrf2inTHP-1macrophagesLilianLohningera,LenkaTomasovaa,b,c,MonikaPraschbergera,Michael..
这些数据表明衣康酸激活Nrf2通过烷基化KEAP1半胱氨酸残基。作者接下来评估衣康酸是否可以激活Nrf2发挥抗炎作用。OI,在不影响细胞活力的的浓度下,可降低lps诱导的Il1b mRNA、pro-IL-1β、HIF-1α和IL-10蛋白水平,细胞外酸化率降低。OI也可降低TLR2和TLR3处理的BMDMs中Il1b mRNA含量。脂多糖诱导的活性氧(ROS)...
目的探讨Keap1/Nrf2/HIF-1α通路在宫颈癌患者中的表达及临床意义.方法选择2017年3月~2018年10月江西省萍乡市湘雅萍矿合作医院治疗的40例宫颈癌患者作为研究对象,所有患者均行手术治疗,术中切除病灶组织及癌旁组织,获得新鲜标本.采用免疫组织...
利用Western Blot法检测Nrf2和HIF-1α蛋白在肺组织的表达.结果表明:1)与对照组相比,模型组小鼠右心室压力明显增加,肺小动脉血管壁明显增厚,管腔变狭窄,右心室与体重的比值显著增加;2)与对照组相比,模型组小鼠肺组织HIF-1α蛋白表达明显增加,而Nrf2蛋白表达明显减少.研究结果意味着:HIF-1α与Nrf2在香烟烟雾法建立...
HO-1和SOD-1蛋白显示出下调趋势(P<0.05,P<0.01或P<0.001),而HIF-1α被上调(P<0.01),SJP干预后上调了Nrf2,HO-1和SOD-1的水平(P<0.01),抑制了HIF-1α的表达(P<0.01).结论升降散能通过调节巨噬细胞M1/M2的免疫平衡改善EAE鼠的临床症状,并减轻病灶的炎症浸润.同时高剂量升降散对Nrf2/HO-1/HIF-1α...
Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1alpha inhibition. Eur J Pharmacol. 2010;630(1–3):121–30. Article CAS PubMed Google Scholar Lou JS, Zhao LP, Huang ZH, Chen XY, Xu JT, Tai WC, Tsim KWK, Chen YT, Xie T. Ginkgetin derived from Ginkgo ...
Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and "cryptic targets" of transcription factors. Chin J Cancer. 2012 Sep;31(9):413-20.A. Ooi and K. A. Furge, "Fumarate hydratase inactivation in renal tumors: HIF1alpha, NRF2, and "cryptic targets" of transcription factors,...
Hypoxia induced production of ROS, Nrf2 and HIF-1α. They were expressed in both sustained and intermittent conditions, but the expression and the activity of P-gp and BCRP were different.#Understanding these mechanisms seems essential in order to propose new therapeutic strategies for patients ...
In addition, both venous hypertension and transcription factor Nrf2 might regulate angiogenesis via upregulation of VEGF and HIF-1α. However, the relationship between venous hypertension and Nrf2 in the pathogenesis of AVMs remains unknown. On the basis of previous studies, we propose that the ...