在这种情况下,HIF-1α的基因靶标之一就是编码细胞因子的IL-1β,IL-1β可导致产生促炎表型。另一种代谢物衣康酸,是在IRG1酶分解线粒体顺式乌头酸后产生的,在LPS刺激巨噬细胞后也会增加。这会导致抗氧化转录因子NRF2上调,从而抑制ROS的产生,因此也可能会降低HIF-1⍺蛋白水平。 另一种糖酵解酶PKM2也被证明...
Nrf2HIF-1 alphaSCUTELLARIA-BAICALENSISDOWN-REGULATIONNRF2RESISTANCECELLSRadiotherapy plays a crucial role in the multimodal treatment of breast cancer. However, radioresistance poses a significant challenge to its effectiveness, hindering successful cancer therapy. Emerging evidence indicates that Nrf2 and HIF-...
张彬等研究发现,冠心丹参方能促进Nrf2/血红素加氧酶1(HO-1)通路改善db/db小鼠肾组织病理变化,降低小鼠Scr和BUN水平,保护肾脏。陈烨等研究显示,玉泉丸可激活糖原合成酶激酶-3β(GSK-3β)/Nrf2抗氧化通路,抑制DKD大鼠肾小球内皮损伤标志物几丁...
Nrf2 plays a key role in cellular antioxidant defences. Under basal conditions, Nrf2 is sequestered by Keap1 (Kelch-like ECH- associated protein) in the cytosol [19]. When challenged by oxi- dants, the complex disrupts and Nrf2 translocates to the nucleus where it leads to the transcription ...
SLC7A11 作为一类胱氨酸转运蛋白,其主要功能是 将细胞外的胱氨酸运输至细胞内,被核因子 E2 相 关因子 2(nuclear factor erythroid 2-related factor 2, Nrf2)[18],干扰素调节因子 1(interferon regulatory factor 1,IRF1)[17],p53[14],HIF-1α[17]等多种转录 因子调节. HIF-1α 是细胞对低氧或缺氧做出...
Fumarate hydratase inactivation in renal tumors: HIF1alpha, NRF2, and ``cryptic targets'' of transcription factors. Chin J Cancer. 2012;31:413-20.A. Ooi, K. A. Furge, "Fumarate hydratase inactivation in renal tumors: HIF1alpha, NRF2, and "cryptic targets" of transcription factors," ...
2.2.5HIF-1α稳定剂DMOG对铁死亡相关指标及HIF-1α/SLC7A11信号通路的影响 (1)DMOG对细胞活力的影响:HSC-T6细胞以5×103个/孔接种至96孔板。待细胞完全贴壁后,使用基础培养基饥饿细胞12 h。分别加入100、300、500 μmol/L的...
However, there have also been studies showing that HIF-1 and NRF2 have inhibitory effects on each other. Therefore, more mechanistic studies are needed to better understand their interactions. In the kidney, the stress-responsive transcription factor FoxO3 was found to reduce oxidative stress and ...
However, there have also been studies showing that HIF-1 and NRF2 have inhibitory effects on each other. Therefore, more mechanistic studies are needed to better understand their interactions. In the kidney, the stress-responsive transcription factor FoxO3 was found to reduce oxidative stress and ...
Molidustat是一种新型的HIF-PH抑制剂,对PHD1, PHD2, PHD3的IC50值分别为480 nM, 280 nM和450 nM。 AKBA AKBA (Acetyl-11-keto-β-boswellic acid) 是一种从乳香中提取出的活性化合物,是新颖的 Nrf2 的活化剂。 Oroxylin A 千层纸素 (Oroxylin A) 是一种有活性的黄酮类化合物,具有较强的抗癌作用。