HIF-1 in T Cells Ameliorates Intestinal Inflammation by Controlling Regulatory T Cell HomeostasisGERD StageComorbid ConditionsPPI UsageIntroduction: The small intestine exhibits a range of slow wave behaviors, including antegrade and retrograde propagation, coordinating motility. It is typically believed that...
cells. We also engineer a probiotic that produces lactate and suppresses T cell autoimmunity through the activation of HIF-1α–NDUFA4L2 signalling in DCs. In summary, we identify an immunometabolic pathway that regulates DC function, and develop a synthetic probiotic for its therapeutic activation....
Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell transplanting therapy. However, these applications are limited since kidney organoid cannot maintain complete morpho
Neuroprotective effect of pAkt and HIF-1α on ischemia rats.Asian Pacific Journal of Tropical Medicine2014;7(3): 221-5. 12.Herrmann JL, Abarbanell AM, Wang Y, et al. Transforming growth factor-α enhances stem cell-mediated postischemic myocardial protection.Annals of Thoracic Surgery2011;92...
[1] Martinez-Outschoorn UE, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle. 2010 Sep 1; 9(17):3515-33. ...
Several Treg surface molecules, such as CTLA4, GITR, CD103, LAG3 and FR4, are also involved in the inhibition of target T-cell activation through cell–cell contact8–10. Tregs are classified into thymus-derived CD4 þ CD25 þ Foxp3 þ Tregs (tTregs), which develop in the thymus ...
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research. ...
KIM-1在肾小管上皮细胞缺氧损伤中的保护作用及HIF-1信号通路调节 第三军医大学博士学位论文 2 FITC Fluorescein isothiocyanate 异硫氰酸荧光素 HGF Hepatocyte growth factor 肝细胞生长因子 HIF Hypoxia inducing factor 缺氧诱导因子 HO Heme Oxygenase 血红素氧化酶 TIM T-cell immunoglobulin mucin protein T 细胞...
Upregulation of HIF-1α can induce apoptosis [7], and recent studies have found that apoptosis can promote the occurrence and development of early tumors [11]. Pyroptosis, also known as cellular inflammatory necrosis, is a type of caspase-1-dependent programmed cell death that mediated by NOD...
HIF-1 alpha deficiency perturbs T and B cell functions The immune system protects organisms from pathogens. The immune cells, in particular T- and B-lymphocytes, develop and acquire effector functions in specia... H Kojima,MV Sitkovsky,M Cascalho - 《Curr Pharm Des》 被引量: 59发表: 2003...