在缺氧条件下,p53可以与HIF1-Alpha直接相互作用,并通过促进MDM2介导的泛素化和蛋白酶体降解来抑制缺氧诱导的HIF1-Alpha表达。此外,在缺氧条件下,HIF1-Alpha可以通过与JAB1(Jun激活结构域结合蛋白-1)和ODD结构域的直接相互作用,从而阻止了与p53的相互作用,进而阻断了p53介导的降解。HIF1-Alpha还可以与HNF4alpha2 (...
Pugh Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J.Biol. Chem. 1999 Jan 22;274(4):2060-71. PubMed ID: 9890965 3. Masson N, Willam C, Maxwell PH, Pugh CW,Ratcliffe PJ Independent function of two destruction ...
在缺氧条件下,p53可以与HIF1-Alpha直接相互作用,并通过促进MDM2介导的泛素化和蛋白酶体降解来抑制缺氧诱导的HIF1-Alpha表达。此外,在缺氧条件下,HIF1-Alpha可以通过与JAB1 (Jun激活结构域结合蛋白-1)和ODD结构域的直接相互作用,从而阻止了与p53的相互作用,进而阻断了p53介导的降解。HIF1-Alpha还可以与HNF4alpha2 ...
HIF1（hypoxia inducible factor-1），中文名低氧诱导因子-1，HIF1是由两个基本的螺旋-环-螺旋PAS（Per-ARNT-Sim）蛋白HIF1-Alpha和HIF1-Beta组成的异二聚体。HIF-1α在缺氧条件下会累积表达，而HIF1β则是组成型表达。HIF-1α通过激活许多基因的转录，作为细胞和全身对缺氧的稳态反应的主要调节因子，包括那些...
10. Peyssonnaux C, et al . Role of the hypoxia inducible factors HIF in iron metabolism.Cell Cycle. 2008 ;7(1):28-32. 11. Takubo K, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.Cell Ste...
中文名称 :缺氧诱导因子1α/HIF-1α 抗体 别名: ARNT interacting protein; ARNT-interacting protein; Basic helix loop helix PAS protein MOP1; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF 1A; HIF 1alpha; HIF-1-alpha; HIF1 A; HIF1 Al...
Arbeit JM.Quiescent hypervascularity mediated by gain of HIF-1 alpha function. Cold Spring Harb Symp Quant Biology . 2002Arbeit JM. 2002. Quiescent hypervascularity mediated by gain of HIF-1 alpha function. Cold Spring Harbor Symposia on Quantitative Biology 67:133 - 142....
4. Peyssonnaux C, et al . Role of the hypoxia inducible factors HIF in iron metabolism.Cell Cycle. 2008 ;7(1):28-32. 5. Takubo K, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.Cell ...
Initially, it was suggested that mutagenesis of these prolines to alanine residues that cannot be hydroxylated generates a constitutively stabilized form of HIF-1alpha, allowing the protein to be expressed independently of oxygen levels. We have investigated the effects on neoangiogenesis by mHIF-1...
HIF-1α基因简介 HIF1(hypoxia inducible factor-1),中文名低氧诱导因子-1,HIF1是由两个基本的螺旋-环-螺旋PAS(Per-ARNT-Sim)蛋白HIF1-Alpha和HIF1-Beta组成的异二聚体。HIF-1α在缺氧条件下会累积表达,而HIF1β则是组成型表达。HIF-1α通过激活许多基因的转录,作为细胞和全身对缺氧的稳态反应的主要调节因...