Pugh Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J.Biol. Chem. 1999 Jan 22;274(4):2060-71. PubMed ID: 9890965 3. Masson N, Willam C, Maxwell PH, Pugh CW,Ratcliffe PJ Independent function of two destruction ...
在缺氧条件下,p53可以与HIF1-Alpha直接相互作用,并通过促进MDM2介导的泛素化和蛋白酶体降解来抑制缺氧诱导的HIF1-Alpha表达。此外,在缺氧条件下,HIF1-Alpha可以通过与JAB1(Jun激活结构域结合蛋白-1)和ODD结构域的直接相互作用,从而阻止了与p53的相互作用,进而阻断了p53介导的降解。HIF1-Alpha还可以与HNF4alpha2 (...
HIF1(hypoxia inducible factor-1),中文名低氧诱导因子-1,HIF1是由两个基本的螺旋-环-螺旋PAS(Per-ARNT-Sim)蛋白HIF1-Alpha和HIF1-Beta组成的异二聚体。HIF-1α在缺氧条件下会累积表达,而HIF1β则是组成型表达。HIF-1α通过激活许多基因的转录,作为细胞和全身对缺氧的稳态反应的主要调节因子,包括那些参与能量...
Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha functionDisclosed herein are novel compositions and methods for the treatment of age- related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension...
Initially, it was suggested that mutagenesis of these prolines to alanine residues that cannot be hydroxylated generates a constitutively stabilized form of HIF-1alpha, allowing the protein to be expressed independently of oxygen levels. We have investigated the effects on neoangiogenesis by mHIF-1...
今天我们要讲的主角是与非酒精性脂肪性肝病（NAFLD）密切相关的HIF-1α基因。HIF-1α基因简介 HIF1（hypoxia inducible factor-1），中文名低氧诱导因子-1，HIF1是由两个基本的螺旋-环-螺旋PAS（Per-ARNT-Sim）蛋白HIF1-Alpha和HIF1-Beta组成的异二聚体。HIF-1α在缺氧条件下会累积表达，而HIF1β则是组成型...
中文名称 :缺氧诱导因子1α/HIF-1α 抗体 别名: ARNT interacting protein; ARNT-interacting protein; Basic helix loop helix PAS protein MOP1; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF 1A; HIF 1alpha; HIF-1-alpha; HIF1 A; HIF1 Al...
10. Peyssonnaux C, et al . Role of the hypoxia inducible factors HIF in iron metabolism.Cell Cycle. 2008 ;7(1):28-32. 11. Takubo K, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.Cell Ste...
Next, 5% bovine serum albumin was added to function as the blocking buffer. The primary antibodies used in our experiment were anti-HIF-1α (D1S7W) and anti-NRP1 (A-12). The corresponding secondary antibodies tagged with Cy3 and FITC were used (1:500, Beyotime Biotechnology). Plasmid ...
3. Masson N, Willam C, Maxwell PH, Pugh CW,Ratcliffe PJ Independent function of two destruction domains inhypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBOJ. 2001 Sep 17;20(18):5197-206. PubMed ID: 11566883 ...