该研究系统阐明了小肠缺氧诱导因子HIF2α-泵铁蛋白FPN(HIF2α-FPN轴)受到抑制,是难治性缺铁贫血、炎性贫血、癌症 Adv Sci:王福俤/闵军霞教授团队发现HIF2α-FPN轴可能成为顽固性贫血治疗靶点
[5] KAELIN W G JR,RATCLIFFE P J JR.Oxygen sensing by metazoans:the central role of the HIF hydroxylase pathway[J].Mol Cell,2008,30(4):393-402. [6] PENG J,ZHANG L,DRYSDALE L,et al.The transcription factor EPAS-1/hypoxia-induci...
在这里,研究者将 USP33 鉴定为必需的去泛素酶,它以 ERK1/2 依赖性方式稳定 HIF-2α 蛋白,以促进癌细胞的缺氧反应。 USP33 在胶质瘤干细胞中优先通过缺氧诱导并与 HIF-2alpha 相互作用,通过去泛素化使其稳定。缺氧后 ERK1/2 的激活促进了 HIF-2α 磷酸化,增强了其与 USP33 的相互作用。 USP33 的沉默...
[5] Maranchie JK, Vasselli JR, Riss J,Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell. 2002 Apr;1(3):247-55. doi: 10....
USP33 在胶质瘤干细胞中优先通过缺氧诱导并与 HIF-2alpha 相互作用,通过去泛素化使其稳定。缺氧后 ERK1/2 的激活促进了 HIF-2α 磷酸化,增强了其与 USP33 的相互作用。 USP33 的沉默破坏了胶质瘤干细胞的维持,减少了肿瘤血管化,并抑制了胶质母细胞瘤的生长。研究者的研究结果强调 USP33 是癌症干细胞缺氧反...
[6] PENG J,ZHANG L,DRYSDALE L,et al.The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling[J].PNAS,2000,97(15):8386-8391. [7] COMPERNOLLE V,BRUSSELMANS K,ACKER T,et al.Loss of HIF-2α and inhibition of VEGF impair fetal lung...
英文名称: Anti-HIF 2 alpha 总访问: 424 国产/进口: 国产 半年访问: 17 产地/品牌: Bioss/博奥森 产品类别: 抗体 规格: 50ul 100ul 200ul 最后更新: 2025-2-13 货号: bs-1447R CAS 号: 参考报价: 50ul/780 100ul/1280 200ul/1980 立即询价 电话咨询 ...
6. Xie, C., et al. Activation of intestinal hypoxia-inducible factor 2alpha during obesity contributes to hepatic steatosis. Nature Medicine 23, 1298-1308 (2017). 7. Zhang, X. Z., et al. Adipocyte hypoxia-inducible factor 2a suppresses atherosclerosis by promoting adipose ceramide catabolism....
Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway. Cell Death Differ 2008; 15: 1472-80.Turchi L, Aberdam E, Mazure N, Pouysse´gur J, Deckert M, et al. (2008) Hif- 2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death ...