糖酵解抑制剂2-Deoxy-d-glucose(2-DG)抑制了野生型(WT)小鼠的过敏原诱导的气道炎症、焦亡、氧化应激和糖酵解,而hif1α稳定剂3,4-二羟基苯甲酸乙酯(EDHB)恢复了TLR2-/-小鼠的这些过敏原诱导的变化,表明TLR2-hif1α介导的糖酵解对AAI的焦亡和氧化应激起作用。此外,在过敏原挑战时,WT小鼠的肺部巨噬细胞被...
We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical. Key ...
To explore the role and mechanism of NF-κB / HIF-1α signaling pathway in the neuroinflammation caused by chronic cerebral hypoperfusion. The chronic cerebral hypoperfusion mouse model was established by unilateral common carotid artery ligation (Unilateral Common Carotid Artery Occlusion UCCAO), random...
Baimai Ointment relieves chronic pain induced by chronic compression of dorsal root ganglion in rats by regulating neuroactive ligand-receptor interaction and HIF-1 signaling pathway 引用 收藏 分享 摘要 具“舒筋活络”核心功效的白脉软膏临床干预疼痛、痉挛、僵硬等症状的白脉病疗效显著,但其药效学特点及...
1 promotes the expression of hundreds of genes involved in cell autonomous and non-autonomous adaptations to hypoxia. Examples of genes and their functions are found in the diagram. HIF-α can be upregulated at the protein level via mTOR or at the mRNA level via STAT3 and NF-κB signaling....
the potential regulatory mechanism of HIF-1α-ROS-NF-κB signaling pathway during the aggravating process of periodontitis induced by psychological stress will be investigated in vivo and in vitro. The whole project is expected to provide new experimental basis for understanding the role of psychology...
Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Activation of HIF-1α signaling has been observed in a series of cancers including gastric cancer. Moreover, a variety of oncogene...
This pathway is important in osteoblasts for differentiation, proliferation and the synthesis bone matrix, whereas osteocytes appear to use the Wnt/尾-... LF Bonewald,ML Johnson - 《Bone》 被引量: 1453发表: 2008年 BMP signaling negatively regulates bone mass through sclerostin by inhibiting the...
(IL-6),hypoxia-inducible factor 1 alpha(HIF-1α)and vascular endothelial growth factors(VEGF)in different types of CRS.And explore the possible mechanism of p38MAPK signaling pathway in CRS.Methods Patients with nasal endoscopic surgery in department of otolaryngology of Qingdao Municipal Hospital ...
www.nature.com/scientificreports OPEN received: 27 January 2016 accepted: 18 May 2016 Published: 06 June 2016 Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia Eun-Taex Oh1,2, Chan Woo Kim3, Soo Jung Kim1,...