[7] Lambein K, Van Bockstal M, Vandemaele L, et al. Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance. Am J Clin Pathol. 2013 Oct;140(4)...
1、HER2与分子靶向治疗：2010年NCCN乳腺癌临床实践指南推荐对于HER2阳性的乳腺癌患者应考虑含曲妥珠单抗的联合辅助化疗方案。2、HER2与内分泌治疗：HER2状态影响肿瘤对激素治疗的反应，HER2阳性的绝经后乳腺癌患者对芳香化酶抑制剂来曲唑的反应优于他莫昔芬。HER2与乳腺癌患者治疗方案的选择 3、HER2与化疗：HER2阳性的...
使用误差矩阵(Confusion Matrix)、准确性(Accuracy)、精准性(Precision)、召回率(Recall)、F1分数(F1-Score,精确性和查全率的调和平均数)和Cohen’s Kappa系数来评价诊断性能;使用组内相关系数(ICC)评价一致性;使用Kruskal-Wallis和Wilcoxon rank-sum检验来分析不同方法诊断准确性的差异。 研究结果 总体研究结果 如下...
同样,HER2 G-ITH与IHC中较低的HER2蛋白表达水平相关:53%(16/30)的1+或2+病例具有HER2 G-ITH,相比之下,9%(2/22)的3+病例具有HER2 G-ITH(P< 0.001)。与无G-ITH的ECs相比,伴有G-ITH的ECs的HER2表达(H-score量化)显著降低(P =0.007,簇状;P<0.002,镶嵌状;图3E)。HER2 G-ITH的ECs没有富集任何特异...
同样,HER2 G-ITH与IHC中较低的HER2蛋白表达水平相关:53%(16/30)的1+或2+病例具有HER2 G-ITH,相比之下,9%(2/22)的3+病例具有HER2 G-ITH(P< 0.001)。与无G-ITH的ECs相比,伴有G-ITH的ECs的HER2表达(H-score量化)显著降低(P =0.007,簇状;P<0.002,镶嵌状;图3E)。HER2 G-ITH的ECs没有富集任何特异...
关键词: invasive breast cancer HER2 immunohistochemistry score 1+ fluorescence in situ hybridization targeted therapies DOI: 10.3892/ol.2016.5125 被引量: 3 年份: 2016 收藏 引用 批量引用 报错 分享 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文。 请先登入相似文献 参考文献 引证文献FISH ...
使用误差矩阵(Confusion Matrix)、准确性(Accuracy)、精准性(Precision)、召回率(Recall)、F1分数(F1-Score,精确性和查全率的调和平均数)和Cohen’s Kappa系数来评价诊断性能;使用组内相关系数(ICC)评价一致性;使用Kruskal-Wallis和Wilcoxon rank-sum检验来分析不同方法诊断准确性的差异。
[4] Schettini F, Chic N, Braso´-Maristany F, et al. Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer. NPJ Breast Cancer 2021;7(1):1. [5] Lambein K, Van Bockstal M, Vandemaele L, et al. Distinguishing score0fromscore1þinHER2immunohistochemistr...
A score of 0 or 1+ indicates no or low expression of Her2, while a score of 2+ is considered equivocal and requiresfurther testing. A score of 3+ indicates high expression of Her2. FISH is a molecular technique that examines the genetic material of tumor cells to determine the presence ...
Differentiating between a HER2 IHC score 0 and score 1 has not been clinically significant until now. To ensure accurate classification and avoid misdiagnosis, it is necessary to adopt standardized procedures, guidelines, and specialized training for pathologists in interpreting HER...