Hepcidin and the iron-infection axis. Science. 2012;338:768-72.Hal Drakesmith,Andrew M. Prentice.Hepcidin and the Iron-Infection Axis[J].2012,Nov.9 TN.6108(Nov.9 TN.6108).Drakesmith H, Prentice AM (2012) Hepcidin and the iron-infection axis. Science 338: 768 - 772...
3. Hepcidin and its receptor ferroportin control systemic iron homeostasis 4. Hepcidin regulation 5. Iron overload disorders due to hepcidin deficiency or resistance to hepcidin 6. Iron-restrictive disorders due to hepcidin excess or ferroportin deficiency 7. Diagnostic and therapeutic potential of hepci...
Parameters of anemia, iron status, inflamation and hepcidin level were evaluated. Results. The HD patients had a significantly lower eritrocyte count, erythrocytes indexes, hemoglobin and transferrin saturation and significantly higher iron, ferritin, hepcidin and total iron binding capacity (TIBC). ...
The increased expression of hepcidin in the liver, induced by inflammation, might be an initial cause of the anemia of infection or chronic diseases and the iron-overload diseases might be tightly associated with the decreased hepcidin expression in the liver. 展开 关键词:...
Hepcidin in elderly Ecuadorians: A link between inflammation, BMI, and iron status. FASEB J. 2011;(25): 779.1.Dao MC, Sempertegui F, Estrella B, Hamer D, Tucker K, Rodriguez A, Dallal G, Griffiths J, Meydani SN. Hepcidin in elderly Ecuadorians: A link between inflammation, BMI, and...
Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron metabolism, and erythropoiesis in chronic hemod
Administration of a recombinant, soluble form of HJV decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores. These results demonstrate that recombinant HJV may be a useful therapeutic agent for treatment of the anemia of chronic disease, a disorder ...
Iron supplementation to treat anemia in patients with chronic kidney disease. Iron deficiency is prevalent in patients with chronic kidney disease (CKD), and use of oral and intravenous iron in patients with CKD who do not require di... A Besarab,DW Coyne - 《Nature Reviews Nephrology》 被...
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many solid tumours, and this is often accompanied by the contemporary rise of two key iron regulators, HIF2α an
This study investigates the roles of HIF-2α, hepcidin, and ghrelin in iron deficiency anemia (IDA), the most widespread nutritional disorder globally.#Fifty IDA patients (18–50years, BMI 19–25) and 40 healthy volunteers were studied. Hemoglobin, ferritin, hepcidin, HIF-2α, and ghrelin le...