iron overloadhepcidinHfelentiviral vectorsHepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages. We showed that mice with β-thalassemia intermedia (th3/+) have increased anemia and iron overload. However, their hepcidin...
HepcidinFerroportinIronoverloadKidneyabstractBackground:Hepcidinisakeyregulatorofironhomeostasis.Somestudiesshowedthatexogenoushepcidindecreasedtheexpressionofdivalentmetaltransporter(DMT1)ratherthanferroportin(FPN1)toregulaterenalironmetabolism.Thisstudyexploredtheeffectsofhepcidinsynthesizedbythekidneyanditsmechanismofiron...
2. Iron homeostasis 3. Hepcidin and its receptor ferroportin control systemic iron homeostasis 4. Hepcidin regulation 5. Iron overload disorders due to hepcidin deficiency or resistance to hepcidin 6. Iron-restrictive disorders due to hepcidin excess or ferroportin deficiency 7. Diagnostic and therapeut...
In this study, very careful measurement of urinary hepcidin is made in severe forms of β-thalassemia, congenital dyserythropoietic anemia, and 2 forms of juvenile hemochromatosis. With rare exceptions, the urinary hepcidin, which should have been very high because of the severe iron overload, was...
Hepcidin mutation in a β-thalassemia major patient with persistent severe iron overload despite chelation therapy[J] . Lorena Duca,Paola Delbini,Isabella Nava,Maria Domenica Cappellini,Anna Meo.Internal and Emergency Medicine . 2010 (1)Duca L, Delbini P, Nava I, et al. Hepcidin mutation in ...
[2] Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program.2011;2011:538–542. [3] Drakesmith H, Nemeth E, Ganz T. Ir...
Alcohol intake and iron overload: Another role for hepcidin? †No abstract is available for this article.doi:10.1002/hep.21544Kris V KowdleyJohn Wiley & Sons, LtdHepatology
Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematol Am Soc Hematol Educ Program. 2011;2011:538–42. ArticleGoogle Scholar Jung M, Mertens C, Tomat E, Brüne B. Iron as a central player and promising target in cancer ...
关键词:铁调素,膜铁转运蛋白,骨形成蛋白,表达调控 Abstract:Hepcidin, a peptide hormone secreted by the liver, constitutes the master regulator of iron homeostasis in mammals.This article reviewed the hepcidin including thebiological charcaterstics,the function and affectingthe expression regulation of hepcid...
Hepcidin itself is regulated by the supply of iron, the need for erythropoiesis, and the state of inflammation. Alterations in hepcidin levels are associated with restricted erythropoiesis, anemia, and iron overload. Discovery of hepcidin and elucidation of its mechanism of action and consequences of...