iron overloadhepcidinHfelentiviral vectorsHepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages. We showed that mice with β-thalassemia intermedia (th3/+) have increased anemia and iron overload. However, their hepcidin...
iron overloadPatients with β-thalassemia major (β-TM) show ineffective erythropoiesis and iron overload, which is the leading cause of mortality and organ injury. The present study aimed to investigate the relationships between two iron regulatory hormones, hepcidin and erythroferrone (ERFE) levels...
2. Iron homeostasis 3. Hepcidin and its receptor ferroportin control systemic iron homeostasis 4. Hepcidin regulation 5. Iron overload disorders due to hepcidin deficiency or resistance to hepcidin 6. Iron-restrictive disorders due to hepcidin excess or ferroportin deficiency 7. Diagnostic and therapeut...
where iron is well tolerated, may be of benefit in iron overload. This also suggests a distinct regulation of ferroportin in hepatocytes compared with enterocytes and macrophages. Either hepcidin has no autocrine effect or this effect is overtaken by other regulatory mechanisms. Hepatocytes physiologica...
The increased expression of hepcidin in the liver, induced by inflammation, might be an initial cause of the anemia of infection or chronic diseases and the iron-overload diseases might be tightly associated with the decreased hepcidin expression in the liver. 展开 关键词:...
The deposition of iron and the consequent hemosiderosis are common features of liver fibrosis, implying that iron overload may be a major risk factor for liver disease progression7. Moreover, iron accumulation may expedite tissue injury by promoting oxidative stress7. Hepcidin (HAMP), a polypeptide...
Our data demonstrate a hetero-tissue crosstalk mechanism, where liver hepcidin regulated intestinal HIF-2α in iron deficiency, anemia, and iron overload. We show that FPN controlled cell autonomous iron efflux to regulate the activity of iron-dependent, intestinal prolyl hydroxylase domain enzymes ...
[2] Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program.2011;2011:538–542. [3] Drakesmith H, Nemeth E, Ganz T. Ir...
These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2α that controls physiological iron uptake and drives iron hyperabsorption during iron overload. 展开 关键词: Gastroenterology DOI: 10.1172/JCI122359 年份: 2019 ...
Increased hepcidin levels result in anemia while decreased expression is the causative feature in most primary iron overload diseases. Mutations in hemochromatosis type 2 (HFE2), which encodes the protein hemojuvelin (HJV), result in the absence of hepcidin and an early-onset form of iron over...