2. Iron homeostasis 3. Hepcidin and its receptor ferroportin control systemic iron homeostasis 4. Hepcidin regulation 5. Iron overload disorders due to hepcidin deficiency or resistance to hepcidin 6. Iron-restrictive disorders due to hepcidin excess or ferroportin deficiency 7. Diagnostic and therapeut...
Hepcidin and iron homeostasis. Biochim. Biophys. Acta 1823, 1434-1443.Ganz T, Nemeth E. Hepcidin and iron homeostasis. Vol. 1823, Biochimica et Biophysica Acta - Molecular Cell Research. 2012. p. 1434-43.Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta 2012; 1823:...
It plays a central role in the regulation of small intestine iron absorption and body iron homeostasis. The increased expression of hepcidin in the liver, induced by inflammation, might be an initial cause of the anemia of infection or chronic diseases and the iron-overload diseases might be ...
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many solid tumours, and this is often accompanied by the contemporary rise of two key iron regulators, HIF2α and Hepcidin. This scenario is different fr...
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many solid tumours, and this is often accompanied by the contemporary rise of two key iron regulators, HIF2α and Hepcidin. This scenario is different fr...
Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree of ...
Ferritin, the iron storage protein, is also pivotal in iron homeostasis [9], [10]. During inflammation, ferritin binds free iron to prevent the formation of harmful free radicals [11]. Its blood levels are boosted independently of iron status during infection and inflammation. It is an acute...
Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications The anemia of chronic disease (ACD) is characterized by macrophage iron retention induced by cytokines and the master regulator hepcidin. Hepcidin controls... I.,Theurl,E.,...
Hepcidin and iron homeostasis. Biochim. Biophys. Acta 1823, 1434–1443 (2012). Article CAS PubMed PubMed Central Google Scholar Theurl, I. et al. Autocrine formation of hepcidin induces iron retention in human monocytes. Blood 111, 2392–2399 (2008). Article CAS PubMed Google Scholar ...
Since the discovery of hepcidin and the demonstration of its pivotal role in iron homeostasis, there has been a substantial interest in developing a ... A Piperno,R Mariani,P Trombini,... - 《World Journal of Gastroenterology》 被引量: 214发表: 2009年 Hepcidin modulation in human diseases:...